Fluorine »
PDB 3oyl-3pr2 »
3pp1 »
Fluorine in PDB 3pp1: Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp
Enzymatic activity of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp
All present enzymatic activity of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp:
2.7.12.2;
2.7.12.2;
Protein crystallography data
The structure of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp, PDB code: 3pp1
was solved by
D.R.Dougan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.70 |
| Space group | P 62 |
| Cell size a, b, c (Å), α, β, γ (°) | 82.086, 82.086, 129.254, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 18.2 / 21.9 |
Other elements in 3pp1:
The structure of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
| Iodine | (I) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp
(pdb code 3pp1). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp, PDB code: 3pp1:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp, PDB code: 3pp1:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 3pp1
Go back to
Fluorine Binding Sites List in 3pp1
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 3pp1
Go back to
Fluorine Binding Sites List in 3pp1
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (Mek 1) in Complex with Ligand and Mgatp within 5.0Å range:
|
Reference:
Q.Dong,
D.R.Dougan,
X.Gong,
P.Halkowycz,
B.Jin,
T.Kanouni,
S.M.O'connell,
N.Scorah,
L.Shi,
M.B.Wallace,
F.Zhou.
Discovery of Tak-733, A Potent and Selective Mek Allosteric Site Inhibitor For the Treatment of Cancer. Bioorg.Med.Chem.Lett. V. 21 1315 2011.
ISSN: ISSN 0960-894X
PubMed: 21310613
DOI: 10.1016/J.BMCL.2011.01.071
Page generated: Wed Jul 31 21:48:41 2024
ISSN: ISSN 0960-894X
PubMed: 21310613
DOI: 10.1016/J.BMCL.2011.01.071
Last articles
Cl in 4BB6Cl in 4BAZ
Cl in 4BAU
Cl in 4BAT
Cl in 4BAD
Cl in 4BAE
Cl in 4B9B
Cl in 4B95
Cl in 4B9D
Cl in 4B98
