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Fluorine in PDB 3qlf: Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
Enzymatic activity of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
All present enzymatic activity of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5:
2.7.10.2;
2.7.10.2;
Protein crystallography data
The structure of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5, PDB code: 3qlf
was solved by
R.Boubeva,
L.Pernot,
R.Perozzo,
L.Scapozza,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 32.95 / 2.75 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.268, 63.495, 73.451, 79.48, 90.09, 89.41 |
| R / Rfree (%) | 19.2 / 23.2 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
(pdb code 3qlf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5, PDB code: 3qlf:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5, PDB code: 3qlf:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 3qlf
Go back to
Fluorine Binding Sites List in 3qlf
Fluorine binding site 1 out
of 6 in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5 within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 3qlf
Go back to
Fluorine Binding Sites List in 3qlf
Fluorine binding site 2 out
of 6 in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5 within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 3qlf
Go back to
Fluorine Binding Sites List in 3qlf
Fluorine binding site 3 out
of 6 in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5 within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 3qlf
Go back to
Fluorine Binding Sites List in 3qlf
Fluorine binding site 4 out
of 6 in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5 within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 3qlf
Go back to
Fluorine Binding Sites List in 3qlf
Fluorine binding site 5 out
of 6 in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5 within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 3qlf
Go back to
Fluorine Binding Sites List in 3qlf
Fluorine binding site 6 out
of 6 in the Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of the L317I Mutant of the C-Src Tyrosine Kinase Domain Complexed with Pyrazolopyrimidine 5 within 5.0Å range:
|
Reference:
R.Boubeva,
L.Pernot,
A.Cristiani,
L.Moretti,
A.Berteotti,
R.Perozzo,
F.Gervasio,
L.Scapozza.
A Single Amino-Acid Dictates the Dynamics of the Switch Between Active and Inactive C-Src Conformation To Be Published.
Page generated: Wed Jul 31 22:05:04 2024
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