|
Atomistry » Fluorine » PDB 3qrj-3rgf » 3qrj | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 3qrj-3rgf » 3qrj » |
Fluorine in PDB 3qrj: The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036Enzymatic activity of The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036
All present enzymatic activity of The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036:
2.7.10.2; Protein crystallography data
The structure of The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036, PDB code: 3qrj
was solved by
W.W.Chan,
S.C.Wise,
M.D.Kaufman,
Y.M.Ahn,
C.L.Ensinger,
T.Haack,
M.M.Hood,
J.Jones,
J.W.Lord,
W.P.Lu,
D.Miller,
W.C.Patt,
B.D.Smith,
P.A.Petillo,
T.J.Rutkoski,
H.Telikepalli,
L.Vogeti,
T.Yao,
L.Chun,
R.Clark,
P.Evangelista,
L.C.Gavrilescu,
K.Lazarides,
V.M.Zaleskas,
L.J.Stewart,
R.A.Van Etten,
D.L.Flynn,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036
(pdb code 3qrj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036, PDB code: 3qrj: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3qrjGo back to Fluorine Binding Sites List in 3qrj
Fluorine binding site 1 out
of 2 in the The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3qrjGo back to Fluorine Binding Sites List in 3qrj
Fluorine binding site 2 out
of 2 in the The Crystal Structure of Human ABL1 Kinase Domain T315I Mutant in Complex with Dcc-2036
Mono view Stereo pair view
Reference:
W.W.Chan,
S.C.Wise,
M.D.Kaufman,
Y.M.Ahn,
C.L.Ensinger,
T.Haack,
M.M.Hood,
J.Jones,
J.W.Lord,
W.P.Lu,
D.Miller,
W.C.Patt,
B.D.Smith,
P.A.Petillo,
T.J.Rutkoski,
H.Telikepalli,
L.Vogeti,
T.Yao,
L.Chun,
R.Clark,
P.Evangelista,
L.C.Gavrilescu,
K.Lazarides,
V.M.Zaleskas,
L.J.Stewart,
R.A.Van Etten,
D.L.Flynn.
Conformational Control Inhibition of the Bcr-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, By the Switch-Control Inhibitor Dcc-2036. Cancer Cell V. 19 556 2011.
Page generated: Sun Dec 13 11:54:00 2020
ISSN: ISSN 1535-6108 PubMed: 21481795 DOI: 10.1016/J.CCR.2011.03.003 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |