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Atomistry » Fluorine » PDB 3qrj-3rgf » 3r17 » |
Fluorine in PDB 3r17: Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) AcetamideEnzymatic activity of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide
All present enzymatic activity of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide:
4.2.1.1; Protein crystallography data
The structure of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide, PDB code: 3r17
was solved by
S.Biswas,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3r17:
The structure of Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide
(pdb code 3r17). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide, PDB code: 3r17: Fluorine binding site 1 out of 1 in 3r17Go back to Fluorine Binding Sites List in 3r17
Fluorine binding site 1 out
of 1 in the Hcarbonic Anhydrase II Bound to N-(2-Fluoro.4-Sulfamoylphenyl)-2- (Thiophen-2-Yl) Acetamide
Mono view Stereo pair view
Reference:
S.Biswas,
M.Aggarwal,
O.Guzel,
A.Scozzafava,
R.Mckenna,
C.T.Supuran.
Conformational Variability of Different Sulfonamide Inhibitors with Thienyl-Acetamido Moieties Attributes to Differential Binding in the Active Site of Cytosolic Human Carbonic Anhydrase Isoforms. Bioorg.Med.Chem. V. 19 3732 2011.
Page generated: Wed Jul 31 22:11:26 2024
ISSN: ISSN 0968-0896 PubMed: 21620713 DOI: 10.1016/J.BMC.2011.05.006 |
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