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Atomistry » Fluorine » PDB 3rjc-3s9y » 3rwp » |
Fluorine in PDB 3rwp: Discovery of A Novel, Potent and Selective Inhibitor of 3- Phosphoinositide Dependent Kinase (PDK1)Enzymatic activity of Discovery of A Novel, Potent and Selective Inhibitor of 3- Phosphoinositide Dependent Kinase (PDK1)
All present enzymatic activity of Discovery of A Novel, Potent and Selective Inhibitor of 3- Phosphoinositide Dependent Kinase (PDK1):
2.7.11.1; Protein crystallography data
The structure of Discovery of A Novel, Potent and Selective Inhibitor of 3- Phosphoinositide Dependent Kinase (PDK1), PDB code: 3rwp
was solved by
S.E.Greasley,
M.Hickey,
R.-A.Ferre,
M.Krauss,
C.Cronin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Discovery of A Novel, Potent and Selective Inhibitor of 3- Phosphoinositide Dependent Kinase (PDK1)
(pdb code 3rwp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Discovery of A Novel, Potent and Selective Inhibitor of 3- Phosphoinositide Dependent Kinase (PDK1), PDB code: 3rwp: Fluorine binding site 1 out of 1 in 3rwpGo back to Fluorine Binding Sites List in 3rwp
Fluorine binding site 1 out
of 1 in the Discovery of A Novel, Potent and Selective Inhibitor of 3- Phosphoinositide Dependent Kinase (PDK1)
Mono view Stereo pair view
Reference:
S.T.Murphy,
G.Alton,
S.Bailey,
S.M.Baxi,
B.J.Burke,
T.A.Chappie,
J.Ermolieff,
R.Ferre,
S.Greasley,
M.Hickey,
J.Humphrey,
N.Kablaoui,
J.Kath,
S.Kazmirski,
M.Kraus,
S.Kupchinsky,
J.Li,
L.Lingardo,
M.A.Marx,
D.Richter,
S.P.Tanis,
K.Tran,
W.Vernier,
Z.Xie,
M.J.Yin,
X.H.Yu.
Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1). J.Med.Chem. V. 54 8490 2011.
Page generated: Sun Dec 13 11:54:52 2020
ISSN: ISSN 0022-2623 PubMed: 22040023 DOI: 10.1021/JM201019K |
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