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Fluorine in PDB 3s2a: Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor
Enzymatic activity of Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor
All present enzymatic activity of Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor:
2.7.1.153;
2.7.1.153;
Protein crystallography data
The structure of Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor, PDB code: 3s2a
was solved by
D.A.Whittington,
J.Tang,
P.Yakowec,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.55 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 144.465, 68.169, 107.347, 90.00, 94.80, 90.00 |
| R / Rfree (%) | 23.4 / 30.1 |
Other elements in 3s2a:
The structure of Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor
(pdb code 3s2a). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor, PDB code: 3s2a:
In total only one binding site of Fluorine was determined in the Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor, PDB code: 3s2a:
Fluorine binding site 1 out of 1 in 3s2a
Go back to
Fluorine Binding Sites List in 3s2a
Fluorine binding site 1 out
of 1 in the Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of PI3K-Gamma in Complex with A Quinoline Inhibitor within 5.0Å range:
|
Reference:
N.Nishimura,
A.Siegmund,
L.Liu,
K.Yang,
M.C.Bryan,
K.L.Andrews,
Y.Bo,
S.K.Booker,
S.Caenepeel,
D.Freeman,
H.Liao,
J.Mccarter,
E.L.Mullady,
T.San Miguel,
R.Subramanian,
N.Tamayo,
L.Wang,
D.A.Whittington,
L.Zalameda,
N.Zhang,
P.E.Hughes,
M.H.Norman.
Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (Mtor) Dual Inhibitors: Discovery and Structure-Activity Relationships of A Series of Quinoline and Quinoxaline Derivatives. J.Med.Chem. V. 54 4735 2011.
ISSN: ISSN 0022-2623
PubMed: 21612232
DOI: 10.1021/JM200386S
Page generated: Sun Dec 13 11:54:59 2020
ISSN: ISSN 0022-2623
PubMed: 21612232
DOI: 10.1021/JM200386S
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