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Fluorine in PDB 3s9y: Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-UmpEnzymatic activity of Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump
All present enzymatic activity of Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump:
4.1.1.23; Protein crystallography data
The structure of Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump, PDB code: 3s9y
was solved by
Y.Liu,
L.P.Kotra,
E.F.Pai,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump
(pdb code 3s9y). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump, PDB code: 3s9y: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 3s9yGo back to Fluorine Binding Sites List in 3s9y
Fluorine binding site 1 out
of 4 in the Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 3s9yGo back to Fluorine Binding Sites List in 3s9y
Fluorine binding site 2 out
of 4 in the Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 3s9yGo back to Fluorine Binding Sites List in 3s9y
Fluorine binding site 3 out
of 4 in the Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 3s9yGo back to Fluorine Binding Sites List in 3s9y
Fluorine binding site 4 out
of 4 in the Crystal Structure of P. Falciparum Orotidine 5'-Monophosphate Decarboxylase Complexed with 5-Fluoro-6-Amino-Ump in Space Group P21, Produced From 5-Fluoro-6-Azido-Ump
Mono view Stereo pair view
Reference:
A.M.Bello,
D.Konforte,
E.Poduch,
C.Furlonger,
L.Wei,
Y.Liu,
M.Lewis,
E.F.Pai,
C.J.Paige,
L.P.Kotra.
Structure-Activity Relationships of Orotidine-5'-Monophosphate Decarboxylase Inhibitors As Anticancer Agents. J.Med.Chem. V. 52 1648 2009.
Page generated: Sun Dec 13 11:55:06 2020
ISSN: ISSN 0022-2623 PubMed: 19260677 DOI: 10.1021/JM801224T |
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