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Fluorine in PDB 3sb0: Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid InhibitorEnzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid Inhibitor
All present enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid Inhibitor:
2.3.3.9; Protein crystallography data
The structure of Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid Inhibitor, PDB code: 3sb0
was solved by
I.V.Krieger,
Q.Sun,
J.C.Sacchettini,
Mycobacterium Tuberculosisstructural Proteomics Project (Xmtb),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3sb0:
The structure of Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid Inhibitor
(pdb code 3sb0). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid Inhibitor, PDB code: 3sb0: Fluorine binding site 1 out of 1 in 3sb0Go back to Fluorine Binding Sites List in 3sb0
Fluorine binding site 1 out
of 1 in the Crystal Structure of Mycobacterium Tuberculosis Malate Synthase in Complex with 4-(2-Chloro-6-Fluoro-3-Methylphenyl)-2,4-Dioxobutanoic Acid Inhibitor
Mono view Stereo pair view
Reference:
I.V.Krieger,
J.S.Freundlich,
V.B.Gawandi,
J.P.Roberts,
V.B.Gawandi,
Q.Sun,
J.L.Owen,
M.T.Fraile,
S.I.Huss,
J.L.Lavandera,
T.R.Ioerger,
J.C.Sacchettini.
Structure-Guided Discovery of Phenyl-Diketo Acids As Potent Inhibitors of M. Tuberculosis Malate Synthase. Chem.Biol. V. 19 1556 2012.
Page generated: Sun Dec 13 11:55:05 2020
ISSN: ISSN 1074-5521 PubMed: 23261599 DOI: 10.1016/J.CHEMBIOL.2012.09.018 |
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