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Fluorine in PDB 3svq: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine

Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine

All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine:
1.14.13.39;

Protein crystallography data

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine, PDB code: 3svq was solved by H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.82 / 2.18
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.751, 111.134, 164.708, 90.00, 90.00, 90.00
R / Rfree (%) 20.9 / 26.2

Other elements in 3svq:

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Zinc (Zn) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine (pdb code 3svq). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine, PDB code: 3svq:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Fluorine binding site 1 out of 8 in 3svq

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Fluorine binding site 1 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F800

b:86.3
occ:1.00
 F15 A:JK4800 0.0 86.3 1.0
C14 A:JK4800 1.3 83.1 1.0
F16 A:JK4800 2.1 84.8 1.0
C21 A:JK4800 2.3 79.9 1.0
C13 A:JK4800 2.3 83.6 1.0
OE1 A:GLU592 2.5 45.0 1.0
N12 A:JK4800 2.6 85.8 1.0
CBA A:HEM750 2.7 55.1 1.0
C26 A:JK4800 2.8 75.1 1.0
CGA A:HEM750 3.4 58.3 1.0
O2A A:HEM750 3.5 59.6 1.0
C22 A:JK4800 3.5 77.7 1.0
CD A:GLU592 3.6 45.9 1.0
C2A A:HEM750 3.6 45.4 1.0
O A:HOH82 3.7 44.2 1.0
C11 A:JK4800 3.8 88.3 1.0
C1A A:HEM750 3.8 45.6 1.0
CAA A:HEM750 3.8 51.3 1.0
C3A A:HEM750 3.9 46.2 1.0
F22 A:JK4800 4.0 77.3 1.0
C25 A:JK4800 4.1 73.4 1.0
OE2 A:GLU592 4.2 42.1 1.0
CHA A:HEM750 4.3 46.9 1.0
C4A A:HEM750 4.3 45.9 1.0
NA A:HEM750 4.3 45.8 1.0
O1A A:HEM750 4.4 57.6 1.0
CMA A:HEM750 4.5 47.5 1.0
C23 A:JK4800 4.6 76.7 1.0
CG A:GLU592 4.6 42.4 1.0
C10 A:JK4800 4.7 90.5 1.0
O09 A:JK4800 4.8 92.9 1.0
C24 A:JK4800 4.9 76.3 1.0

Fluorine binding site 2 out of 8 in 3svq

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Fluorine binding site 2 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F800

b:84.8
occ:1.00
 F16 A:JK4800 0.0 84.8 1.0
C14 A:JK4800 1.3 83.1 1.0
F15 A:JK4800 2.1 86.3 1.0
C13 A:JK4800 2.3 83.6 1.0
C21 A:JK4800 2.4 79.9 1.0
F22 A:JK4800 2.6 77.3 1.0
C22 A:JK4800 2.8 77.7 1.0
N12 A:JK4800 2.8 85.8 1.0
CG2 A:VAL567 3.3 36.5 1.0
C11 A:JK4800 3.3 88.3 1.0
C26 A:JK4800 3.6 75.1 1.0
CBA A:HEM750 3.8 55.1 1.0
CHA A:HEM750 4.0 46.9 1.0
C23 A:JK4800 4.1 76.7 1.0
C1A A:HEM750 4.1 45.6 1.0
C4D A:HEM750 4.3 48.3 1.0
OE1 A:GLU592 4.4 45.0 1.0
O2A A:HEM750 4.4 59.6 1.0
NA A:HEM750 4.6 45.8 1.0
C2A A:HEM750 4.6 45.4 1.0
C10 A:JK4800 4.6 90.5 1.0
CGA A:HEM750 4.7 58.3 1.0
ND A:HEM750 4.7 43.9 1.0
CBD A:HEM750 4.7 55.7 1.0
CB A:VAL567 4.7 43.6 1.0
C25 A:JK4800 4.8 73.4 1.0
O09 A:JK4800 4.8 92.9 1.0
F23 A:JK4800 4.8 79.9 1.0
C3D A:HEM750 4.8 47.5 1.0
C24 A:JK4800 4.9 76.3 1.0
CAA A:HEM750 4.9 51.3 1.0
FE A:HEM750 5.0 43.7 1.0
O A:HOH82 5.0 44.2 1.0

Fluorine binding site 3 out of 8 in 3svq

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Fluorine binding site 3 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F800

b:77.3
occ:1.00
 F22 A:JK4800 0.0 77.3 1.0
C22 A:JK4800 1.3 77.7 1.0
C23 A:JK4800 2.2 76.7 1.0
C21 A:JK4800 2.4 79.9 1.0
F23 A:JK4800 2.4 79.9 1.0
F16 A:JK4800 2.6 84.8 1.0
C14 A:JK4800 2.9 83.1 1.0
CG2 A:VAL567 3.0 36.5 1.0
C13 A:JK4800 3.5 83.6 1.0
C24 A:JK4800 3.5 76.3 1.0
C26 A:JK4800 3.6 75.1 1.0
CE1 A:PHE584 3.9 43.6 1.0
F15 A:JK4800 4.0 86.3 1.0
CB A:VAL567 4.1 43.6 1.0
C25 A:JK4800 4.1 73.4 1.0
FE A:HEM750 4.5 43.7 1.0
CD1 A:PHE584 4.5 40.5 1.0
N A:VAL567 4.5 43.0 1.0
O A:PRO565 4.5 42.2 1.0
NC A:HEM750 4.5 41.1 1.0
ND A:HEM750 4.7 43.9 1.0
N12 A:JK4800 4.7 85.8 1.0
CB A:PRO565 4.8 40.6 1.0
C A:PRO565 4.8 41.5 1.0
C1C A:HEM750 4.8 42.6 1.0
CA A:VAL567 4.9 43.5 1.0
CZ A:PHE584 4.9 37.0 1.0
NB A:HEM750 4.9 42.8 1.0
N A:ALA566 4.9 42.9 1.0
C4C A:HEM750 5.0 40.7 1.0
O A:PHE584 5.0 40.1 1.0
C4D A:HEM750 5.0 48.3 1.0
C1D A:HEM750 5.0 46.1 1.0

Fluorine binding site 4 out of 8 in 3svq

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Fluorine binding site 4 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F800

b:79.9
occ:1.00
 F23 A:JK4800 0.0 79.9 1.0
C23 A:JK4800 1.4 76.7 1.0
C22 A:JK4800 2.3 77.7 1.0
F22 A:JK4800 2.4 77.3 1.0
C24 A:JK4800 2.5 76.3 1.0
N A:GLY586 3.1 42.0 1.0
CHC A:HEM750 3.3 43.6 1.0
C1C A:HEM750 3.3 42.6 1.0
C21 A:JK4800 3.6 79.9 1.0
C A:SER585 3.7 40.5 1.0
C25 A:JK4800 3.7 73.4 1.0
O A:PRO565 3.7 42.2 1.0
C4B A:HEM750 3.8 43.3 1.0
NC A:HEM750 3.8 41.1 1.0
CA A:GLY586 3.8 42.1 1.0
CA A:SER585 3.9 39.8 1.0
C2C A:HEM750 4.0 43.4 1.0
NB A:HEM750 4.1 42.8 1.0
C26 A:JK4800 4.1 75.1 1.0
CD1 A:PHE584 4.3 40.5 1.0
FE A:HEM750 4.4 43.7 1.0
CE1 A:PHE584 4.4 43.6 1.0
O A:SER585 4.5 40.1 1.0
C4C A:HEM750 4.5 40.7 1.0
CMC A:HEM750 4.5 39.2 1.0
N A:SER585 4.5 38.5 1.0
C3C A:HEM750 4.6 40.0 1.0
C A:PRO565 4.6 41.5 1.0
CG A:PRO565 4.6 39.8 1.0
C A:GLY586 4.6 43.6 1.0
C3B A:HEM750 4.6 43.3 1.0
O A:PHE584 4.7 40.1 1.0
CB A:PRO565 4.7 40.6 1.0
C14 A:JK4800 4.7 83.1 1.0
N A:TRP587 4.7 42.8 1.0
F16 A:JK4800 4.8 84.8 1.0
C A:PHE584 4.9 39.1 1.0
C1B A:HEM750 4.9 44.6 1.0

Fluorine binding site 5 out of 8 in 3svq

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Fluorine binding site 5 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F800

b:78.8
occ:1.00
 F15 B:JK4800 0.0 78.8 1.0
C14 B:JK4800 1.3 73.2 1.0
F16 B:JK4800 2.1 73.2 1.0
C21 B:JK4800 2.3 68.3 1.0
C13 B:JK4800 2.3 71.4 1.0
CBA B:HEM750 2.5 52.2 1.0
OE1 B:GLU592 2.7 46.0 1.0
C26 B:JK4800 2.7 64.7 1.0
N12 B:JK4800 2.8 72.3 1.0
O2A B:HEM750 3.0 59.3 1.0
CGA B:HEM750 3.2 55.3 1.0
C2A B:HEM750 3.3 44.6 1.0
O B:HOH19 3.4 48.9 1.0
CAA B:HEM750 3.5 51.1 1.0
C22 B:JK4800 3.6 67.8 1.0
C1A B:HEM750 3.7 47.0 1.0
C3A B:HEM750 3.7 45.1 1.0
CD B:GLU592 3.8 46.3 1.0
C25 B:JK4800 4.1 61.6 1.0
CHA B:HEM750 4.2 45.2 1.0
F22 B:JK4800 4.2 72.6 1.0
C11 B:JK4800 4.2 73.4 1.0
C4A B:HEM750 4.3 45.1 1.0
CMA B:HEM750 4.3 43.8 1.0
NA B:HEM750 4.3 45.5 1.0
O1A B:HEM750 4.4 57.3 1.0
OE2 B:GLU592 4.4 40.9 1.0
C23 B:JK4800 4.7 64.8 1.0
CG B:GLU592 4.7 43.0 1.0
C24 B:JK4800 4.9 64.5 1.0
C4D B:HEM750 4.9 46.2 1.0

Fluorine binding site 6 out of 8 in 3svq

Go back to Fluorine Binding Sites List in 3svq
Fluorine binding site 6 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F800

b:73.2
occ:1.00
 F16 B:JK4800 0.0 73.2 1.0
C14 B:JK4800 1.3 73.2 1.0
F15 B:JK4800 2.1 78.8 1.0
C13 B:JK4800 2.4 71.4 1.0
C21 B:JK4800 2.4 68.3 1.0
F22 B:JK4800 2.8 72.6 1.0
N12 B:JK4800 2.8 72.3 1.0
C22 B:JK4800 2.9 67.8 1.0
CG2 B:VAL567 3.5 38.3 1.0
C26 B:JK4800 3.6 64.7 1.0
CHA B:HEM750 3.8 45.2 1.0
C1A B:HEM750 3.9 47.0 1.0
O2A B:HEM750 3.9 59.3 1.0
C4D B:HEM750 4.0 46.2 1.0
CBA B:HEM750 4.0 52.2 1.0
C11 B:JK4800 4.0 73.4 1.0
C23 B:JK4800 4.2 64.8 1.0
C2A B:HEM750 4.3 44.6 1.0
ND B:HEM750 4.4 41.8 1.0
CBD B:HEM750 4.4 51.1 1.0
CGA B:HEM750 4.5 55.3 1.0
NA B:HEM750 4.5 45.5 1.0
C3D B:HEM750 4.5 46.3 1.0
CAA B:HEM750 4.5 51.1 1.0
OE1 B:GLU592 4.6 46.0 1.0
C25 B:JK4800 4.8 61.6 1.0
FE B:HEM750 4.9 43.0 1.0
F23 B:JK4800 4.9 64.1 1.0
CB B:VAL567 4.9 40.9 1.0
C3A B:HEM750 4.9 45.1 1.0
O B:HOH19 4.9 48.9 1.0
C24 B:JK4800 5.0 64.5 1.0

Fluorine binding site 7 out of 8 in 3svq

Go back to Fluorine Binding Sites List in 3svq
Fluorine binding site 7 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F800

b:72.6
occ:1.00
 F22 B:JK4800 0.0 72.6 1.0
C22 B:JK4800 1.3 67.8 1.0
C23 B:JK4800 2.2 64.8 1.0
F23 B:JK4800 2.4 64.1 1.0
C21 B:JK4800 2.4 68.3 1.0
F16 B:JK4800 2.8 73.2 1.0
C14 B:JK4800 3.0 73.2 1.0
CG2 B:VAL567 3.3 38.3 1.0
C24 B:JK4800 3.5 64.5 1.0
C13 B:JK4800 3.6 71.4 1.0
C26 B:JK4800 3.6 64.7 1.0
CE1 B:PHE584 3.7 39.8 1.0
C25 B:JK4800 4.1 61.6 1.0
CB B:VAL567 4.2 40.9 1.0
F15 B:JK4800 4.2 78.8 1.0
CD1 B:PHE584 4.2 35.7 1.0
FE B:HEM750 4.5 43.0 1.0
NC B:HEM750 4.5 45.4 1.0
N B:VAL567 4.5 40.3 1.0
CZ B:PHE584 4.6 41.3 1.0
ND B:HEM750 4.6 41.8 1.0
O B:PRO565 4.7 38.1 1.0
N12 B:JK4800 4.7 72.3 1.0
C4C B:HEM750 4.8 43.4 1.0
C1C B:HEM750 4.9 44.0 1.0
C1D B:HEM750 4.9 42.8 1.0
C B:PRO565 5.0 39.8 1.0
C4D B:HEM750 5.0 46.2 1.0
CB B:PRO565 5.0 39.1 1.0

Fluorine binding site 8 out of 8 in 3svq

Go back to Fluorine Binding Sites List in 3svq
Fluorine binding site 8 out of 8 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3R,4R)-4-(2-((2,2-Difluoro-2-(2,3-Difluorophenyl)Ethyl) Amino)Ethoxy)Pyrrolidin-3-Yl)Methyl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F800

b:64.1
occ:1.00
 F23 B:JK4800 0.0 64.1 1.0
C23 B:JK4800 1.3 64.8 1.0
C22 B:JK4800 2.2 67.8 1.0
F22 B:JK4800 2.4 72.6 1.0
C24 B:JK4800 2.4 64.5 1.0
N B:GLY586 3.2 38.5 1.0
C21 B:JK4800 3.5 68.3 1.0
C1C B:HEM750 3.6 44.0 1.0
CHC B:HEM750 3.6 43.9 1.0
C25 B:JK4800 3.7 61.6 1.0
C B:SER585 3.7 37.9 1.0
O B:PRO565 3.8 38.1 1.0
C4B B:HEM750 3.8 45.3 1.0
CA B:SER585 3.9 37.5 1.0
CA B:GLY586 3.9 39.6 1.0
NC B:HEM750 4.0 45.4 1.0
C26 B:JK4800 4.0 64.7 1.0
C2C B:HEM750 4.1 45.2 1.0
NB B:HEM750 4.3 44.0 1.0
CD1 B:PHE584 4.3 35.7 1.0
CE1 B:PHE584 4.4 39.8 1.0
C3B B:HEM750 4.4 45.0 1.0
FE B:HEM750 4.5 43.0 1.0
C4C B:HEM750 4.5 43.4 1.0
CG B:PRO565 4.6 40.4 1.0
O B:SER585 4.6 37.2 1.0
N B:SER585 4.6 36.3 1.0
CMC B:HEM750 4.6 47.9 1.0
C3C B:HEM750 4.6 42.9 1.0
C B:PRO565 4.6 39.8 1.0
C B:GLY586 4.7 40.7 1.0
CB B:PRO565 4.7 39.1 1.0
O B:PHE584 4.8 34.0 1.0
C14 B:JK4800 4.8 73.2 1.0
N B:TRP587 4.8 40.3 1.0
F16 B:JK4800 4.9 73.2 1.0
CAB B:HEM750 4.9 47.9 1.0
C B:PHE584 5.0 36.9 1.0
C1B B:HEM750 5.0 44.0 1.0

Reference:

F.Xue, J.M.Kraus, K.J.Labby, H.Ji, J.Mataka, G.Xia, H.Li, S.L.Delker, L.J.Roman, P.Martasek, T.L.Poulos, R.B.Silverman. Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase. J.Med.Chem. V. 54 6399 2011.
ISSN: ISSN 0022-2623
PubMed: 21809851
DOI: 10.1021/JM200411J
Page generated: Wed Jul 31 22:38:38 2024

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