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Fluorine in PDB 3tag: 5-Fluorocytosine Paired with Damp in RB69 GP43

Enzymatic activity of 5-Fluorocytosine Paired with Damp in RB69 GP43

All present enzymatic activity of 5-Fluorocytosine Paired with Damp in RB69 GP43:
2.7.7.7;

Protein crystallography data

The structure of 5-Fluorocytosine Paired with Damp in RB69 GP43, PDB code: 3tag was solved by K.E.Zahn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.95 / 2.95
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 132.771, 123.028, 165.184, 90.00, 96.39, 90.00
R / Rfree (%) 23.9 / 28.4

Fluorine Binding Sites:

The binding sites of Fluorine atom in the 5-Fluorocytosine Paired with Damp in RB69 GP43 (pdb code 3tag). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the 5-Fluorocytosine Paired with Damp in RB69 GP43, PDB code: 3tag:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 3tag

Go back to Fluorine Binding Sites List in 3tag
Fluorine binding site 1 out of 2 in the 5-Fluorocytosine Paired with Damp in RB69 GP43


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of 5-Fluorocytosine Paired with Damp in RB69 GP43 within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F3

b:0.7
occ:1.00
F E:C373 0.0 0.7 1.0
C5 E:C373 1.3 0.8 1.0
C6 E:C373 2.3 0.9 1.0
C4 E:C373 2.4 0.2 1.0
N4 E:C373 2.8 0.5 1.0
N1 E:C373 3.6 0.3 1.0
N3 E:C373 3.6 0.8 1.0
C2 E:C373 4.1 0.7 1.0
O A:LYS278 4.3 82.4 1.0
C1' E:C373 4.8 0.3 1.0
NZ A:LYS279 5.0 91.1 1.0
O6 E:DG4 5.0 0.0 1.0

Fluorine binding site 2 out of 2 in 3tag

Go back to Fluorine Binding Sites List in 3tag
Fluorine binding site 2 out of 2 in the 5-Fluorocytosine Paired with Damp in RB69 GP43


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of 5-Fluorocytosine Paired with Damp in RB69 GP43 within 5.0Å range:
probe atom residue distance (Å) B Occ
I:F3

b:92.6
occ:1.00
F I:C373 0.0 92.6 1.0
C5 I:C373 1.3 94.2 1.0
C6 I:C373 2.3 92.8 1.0
C4 I:C373 2.4 95.2 1.0
N4 I:C373 2.8 95.1 1.0
NZ C:LYS279 2.9 58.7 1.0
N1 I:C373 3.6 91.6 1.0
N3 I:C373 3.6 93.8 1.0
C2 I:C373 4.1 92.2 1.0
CE C:LYS279 4.1 56.3 1.0
C1' I:C373 4.8 88.1 1.0
CD C:LYS279 4.8 53.8 1.0
C2' I:C373 5.0 87.0 1.0

Reference:

K.E.Zahn, A.Averill, S.S.Wallace, S.Doublie. The Miscoding Potential of 5-Hydroxycytosine Arises Due to Template Instability in the Replicative Polymerase Active Site. Biochemistry V. 50 10350 2011.
ISSN: ISSN 0006-2960
PubMed: 22026756
DOI: 10.1021/BI201219S
Page generated: Wed Jul 31 22:42:36 2024

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