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Fluorine in PDB 3tcp: Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569
Enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569
All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569, PDB code: 3tcp
was solved by
J.Liu,
C.Yang,
C.Simpson,
D.Deryckere,
A.Van Deusen,
M.Miley,
D.B.Kireev,
J.Norris-Drouin,
S.Sather,
D.Hunter,
H.S.Patel,
W.P.Janzen,
M.Machius,
G.Johnson,
H.S.Earp,
D.K.Graham,
S.Frye,
X.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.02 / 2.69 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.158, 91.142, 68.356, 90.00, 100.35, 90.00 |
| R / Rfree (%) | 22.5 / 29.8 |
Other elements in 3tcp:
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569 also contains other interesting chemical elements:
| Chlorine | (Cl) | 3 atoms |
| Calcium | (Ca) | 3 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569
(pdb code 3tcp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569, PDB code: 3tcp:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569, PDB code: 3tcp:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 3tcp
Go back to
Fluorine Binding Sites List in 3tcp
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569 within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 3tcp
Go back to
Fluorine Binding Sites List in 3tcp
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC569 within 5.0Å range:
|
Reference:
J.Liu,
C.Yang,
C.Simpson,
D.Deryckere,
A.Van Deusen,
M.J.Miley,
D.Kireev,
J.Norris-Drouin,
S.Sather,
D.Hunter,
V.K.Korboukh,
H.S.Patel,
W.P.Janzen,
M.Machius,
G.L.Johnson,
H.S.Earp,
D.K.Graham,
S.V.Frye,
X.Wang.
Discovery of Novel Small Molecule Mer Kinase Inhibitors For the Treatment of Pediatric Acute Lymphoblastic Leukemia. Acs Med Chem Lett V. 3 129 2012.
ISSN: ISSN 1948-5875
PubMed: 22662287
Page generated: Wed Jul 31 22:42:29 2024
ISSN: ISSN 1948-5875
PubMed: 22662287
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