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Fluorine in PDB 3tpx: Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Protein crystallography data
The structure of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor, PDB code: 3tpx
was solved by
X.Wu,
M.Pazgier,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.80 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 70.532, 211.811, 45.327, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.8 / 23.1 |
Other elements in 3tpx:
The structure of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor also contains other interesting chemical elements:
| Chlorine | (Cl) | 5 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
(pdb code 3tpx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 9 binding sites of Fluorine where determined in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor, PDB code: 3tpx:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;
In total 9 binding sites of Fluorine where determined in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor, PDB code: 3tpx:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;
Fluorine binding site 1 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 1 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 2 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 3 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 4 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 5 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 6 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 7 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 7 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 8 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 8 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Fluorine binding site 9 out of 9 in 3tpx
Go back to
Fluorine Binding Sites List in 3tpx
Fluorine binding site 9 out
of 9 in the Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 9 of Crystal Structure of Human MDM2 in Complex with A Trifluoromethylated D-Peptide Inhibitor within 5.0Å range:
|
Reference:
C.Zhan,
L.Zhao,
X.Wei,
X.Wu,
X.Chen,
W.Yuan,
W.Y.Lu,
M.Pazgier,
W.Lu.
An Ultrahigh Affinity D-Peptide Antagonist of MDM2. J.Med.Chem. V. 55 6237 2012.
ISSN: ISSN 0022-2623
PubMed: 22694121
DOI: 10.1021/JM3005465
Page generated: Wed Jul 31 22:45:02 2024
ISSN: ISSN 0022-2623
PubMed: 22694121
DOI: 10.1021/JM3005465
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