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Atomistry » Fluorine » PDB 3syn-3u2o » 3tyl » |
Fluorine in PDB 3tyl: Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-AmineEnzymatic activity of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine
All present enzymatic activity of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine, PDB code: 3tyl
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3tyl:
The structure of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine
(pdb code 3tyl). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine, PDB code: 3tyl: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3tylGo back to Fluorine Binding Sites List in 3tyl
Fluorine binding site 1 out
of 2 in the Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3tylGo back to Fluorine Binding Sites List in 3tyl
Fluorine binding site 2 out
of 2 in the Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine
Mono view Stereo pair view
Reference:
K.J.Labby,
F.Xue,
J.M.Kraus,
H.Ji,
J.Mataka,
H.Li,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Intramolecular Hydrogen Bonding: A Potential Strategy For More Bioavailable Inhibitors of Neuronal Nitric Oxide Synthase. Bioorg.Med.Chem. V. 20 2435 2012.
Page generated: Wed Jul 31 22:48:58 2024
ISSN: ISSN 0968-0896 PubMed: 22370337 DOI: 10.1016/J.BMC.2012.01.037 |
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