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Atomistry » Fluorine » PDB 3u5k-3uxm » 3ug2 » |
Fluorine in PDB 3ug2: Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with GefitinibEnzymatic activity of Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with Gefitinib
All present enzymatic activity of Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with Gefitinib:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with Gefitinib, PDB code: 3ug2
was solved by
L.J.Parker,
N.Handa,
S.Yoshikawa,
M.Kukimoto-Niino,
M.Shirouzu,
S.Yokoyama,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3ug2:
The structure of Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with Gefitinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with Gefitinib
(pdb code 3ug2). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with Gefitinib, PDB code: 3ug2: Fluorine binding site 1 out of 1 in 3ug2Go back to Fluorine Binding Sites List in 3ug2
Fluorine binding site 1 out
of 1 in the Crystal Structure of the Mutated Egfr Kinase Domain (G719S/T790M) in Complex with Gefitinib
Mono view Stereo pair view
Reference:
S.Yoshikawa,
M.Kukimoto-Niino,
L.Parker,
N.Handa,
T.Terada,
T.Fujimoto,
Y.Terazawa,
M.Wakiyama,
M.Sato,
S.Sano,
T.Kobayashi,
T.Tanaka,
L.Chen,
Z.J.Liu,
B.C.Wang,
M.Shirouzu,
S.Kawa,
K.Semba,
T.Yamamoto,
S.Yokoyama.
Structural Basis For the Altered Drug Sensitivities of Non-Small Cell Lung Cancer-Associated Mutants of Human Epidermal Growth Factor Receptor Oncogene V. 32 27 2013.
Page generated: Sun Dec 13 11:56:28 2020
ISSN: ISSN 0950-9232 PubMed: 22349823 DOI: 10.1038/ONC.2012.21 |
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