Fluorine »
PDB 3uyt-3vrb »
3vhe »
Fluorine in PDB 3vhe: Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Enzymatic activity of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
All present enzymatic activity of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor., PDB code: 3vhe
was solved by
Y.Oguro,
N.Miyamoto,
K.Okada,
T.Takagi,
H.Iwata,
Y.Awazu,
H.Miki,
A.Hori,
K.Kamiyama,
S.Imanura,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.84 / 1.55 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 134.340, 56.270, 52.070, 90.00, 95.24, 90.00 |
| R / Rfree (%) | n/a / n/a |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
(pdb code 3vhe). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor., PDB code: 3vhe:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor., PDB code: 3vhe:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 1 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 2 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 3 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 4 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Reference:
Y.Oguro,
N.Miyamoto,
K.Okada,
T.Takagi,
H.Iwata,
Y.Awazu,
H.Miki,
A.Hori,
K.Kamiyama,
S.Imamura.
Design, Synthesis, and Evaluation of 5-Methyl-4-Phenoxy-5H-Pyrrolo[3,2-D]Pyrimidine Derivatives: Novel VEGFR2 Kinase Inhibitors Binding to Inactive Kinase Conformation. Bioorg.Med.Chem. V. 18 7260 2010.
ISSN: ISSN 0968-0896
PubMed: 20833055
DOI: 10.1016/J.BMC.2010.08.017
Page generated: Wed Jul 31 23:17:40 2024
ISSN: ISSN 0968-0896
PubMed: 20833055
DOI: 10.1016/J.BMC.2010.08.017
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
