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Fluorine in PDB 3vhe: Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Enzymatic activity of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
All present enzymatic activity of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor., PDB code: 3vhe
was solved by
Y.Oguro,
N.Miyamoto,
K.Okada,
T.Takagi,
H.Iwata,
Y.Awazu,
H.Miki,
A.Hori,
K.Kamiyama,
S.Imanura,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.84 / 1.55 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 134.340, 56.270, 52.070, 90.00, 95.24, 90.00 |
| R / Rfree (%) | n/a / n/a |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
(pdb code 3vhe). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor., PDB code: 3vhe:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor., PDB code: 3vhe:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 1 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 2 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 3 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 3vhe
Go back to
Fluorine Binding Sites List in 3vhe
Fluorine binding site 4 out
of 4 in the Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Human VEGFR2 Kinase Domain with A Novel Pyrrolopyrimidine Inhibitor. within 5.0Å range:
|
Reference:
Y.Oguro,
N.Miyamoto,
K.Okada,
T.Takagi,
H.Iwata,
Y.Awazu,
H.Miki,
A.Hori,
K.Kamiyama,
S.Imamura.
Design, Synthesis, and Evaluation of 5-Methyl-4-Phenoxy-5H-Pyrrolo[3,2-D]Pyrimidine Derivatives: Novel VEGFR2 Kinase Inhibitors Binding to Inactive Kinase Conformation. Bioorg.Med.Chem. V. 18 7260 2010.
ISSN: ISSN 0968-0896
PubMed: 20833055
DOI: 10.1016/J.BMC.2010.08.017
Page generated: Sun Dec 13 11:57:03 2020
ISSN: ISSN 0968-0896
PubMed: 20833055
DOI: 10.1016/J.BMC.2010.08.017
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