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Atomistry » Fluorine » PDB 3wyl-460d » 3wze » |
Fluorine in PDB 3wze: Kdr in Complex with Ligand SorafenibEnzymatic activity of Kdr in Complex with Ligand Sorafenib
All present enzymatic activity of Kdr in Complex with Ligand Sorafenib:
2.7.10.1; Protein crystallography data
The structure of Kdr in Complex with Ligand Sorafenib, PDB code: 3wze
was solved by
K.Okamoto,
M.Ikemori_Kawada,
A.Inoue,
J.Matsui,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3wze:
The structure of Kdr in Complex with Ligand Sorafenib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Kdr in Complex with Ligand Sorafenib
(pdb code 3wze). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Kdr in Complex with Ligand Sorafenib, PDB code: 3wze: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 3wzeGo back to Fluorine Binding Sites List in 3wze
Fluorine binding site 1 out
of 3 in the Kdr in Complex with Ligand Sorafenib
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 3wzeGo back to Fluorine Binding Sites List in 3wze
Fluorine binding site 2 out
of 3 in the Kdr in Complex with Ligand Sorafenib
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 3wzeGo back to Fluorine Binding Sites List in 3wze
Fluorine binding site 3 out
of 3 in the Kdr in Complex with Ligand Sorafenib
Mono view Stereo pair view
Reference:
K.Okamoto,
M.Ikemori-Kawada,
A.Jestel,
K.Von Konig,
Y.Funahashi,
T.Matsushima,
A.Tsuruoka,
A.Inoue,
J.Matsui.
Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed By Biochemical Characterization. Acs Med.Chem.Lett. V. 6 89 2015.
Page generated: Sun Dec 13 11:57:55 2020
ISSN: ISSN 1948-5875 PubMed: 25589937 DOI: 10.1021/ML500394M |
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