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Atomistry » Fluorine » PDB 3wyl-460d » 3zbf » |
Fluorine in PDB 3zbf: Structure of Human ROS1 Kinase Domain in Complex with CrizotinibEnzymatic activity of Structure of Human ROS1 Kinase Domain in Complex with Crizotinib
All present enzymatic activity of Structure of Human ROS1 Kinase Domain in Complex with Crizotinib:
2.7.10.1; Protein crystallography data
The structure of Structure of Human ROS1 Kinase Domain in Complex with Crizotinib, PDB code: 3zbf
was solved by
M.Mctigue,
Y.Deng,
W.Liu,
A.Brooun,
A.Stewart,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3zbf:
The structure of Structure of Human ROS1 Kinase Domain in Complex with Crizotinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human ROS1 Kinase Domain in Complex with Crizotinib
(pdb code 3zbf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Human ROS1 Kinase Domain in Complex with Crizotinib, PDB code: 3zbf: Fluorine binding site 1 out of 1 in 3zbfGo back to Fluorine Binding Sites List in 3zbf
Fluorine binding site 1 out
of 1 in the Structure of Human ROS1 Kinase Domain in Complex with Crizotinib
Mono view Stereo pair view
Reference:
M.M.Awad,
R.Katayama,
M.Mctigue,
W.Liu,
Y.Deng,
A.Brooun,
L.Friboulet,
D.Huang,
M.D.Falk,
S.Timofeevski,
K.D.Wilner,
E.L.Lockerman,
T.M.Khan,
S.Mahmood,
J.F.Gainor,
S.R.Digumarthy,
J.R.Stone,
M.Mino-Kenudson,
J.G.Christensen,
J.Iafrate,
J.A.Engelman,
A.T.Shaw.
Acquired Resistance to Crizotinib From A Mutation in CD74-ROS1 N.Engl.J.Med. V. 368 2395 2013.
Page generated: Sun Dec 13 11:57:57 2020
ISSN: ISSN 0028-4793 PubMed: 23724914 DOI: 10.1056/NEJMOA1215530 |
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