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Atomistry » Fluorine » PDB 4b00-4bjk » 4b00 » |
Fluorine in PDB 4b00: Design and Synthesis of BACE1 Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides (Compound (R)-41)Enzymatic activity of Design and Synthesis of BACE1 Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides (Compound (R)-41)
All present enzymatic activity of Design and Synthesis of BACE1 Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides (Compound (R)-41):
3.4.23.46; Protein crystallography data
The structure of Design and Synthesis of BACE1 Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides (Compound (R)-41), PDB code: 4b00
was solved by
B.M.Swahn,
K.Kolmodin,
S.Karlstrom,
S.Von Berg,
P.Soderman,
J.Holenz,
S.Berg,
J.Lindstrom,
M.Sundstrom,
D.Turek,
J.Kihlstrom,
C.Slivo,
L.Andersson,
D.Pyring,
L.Ohberg,
A.Kers,
K.Bogar,
M.Bergh,
L.L.Olsson,
J.Janson,
S.Eketjall,
B.Georgievska,
F.Jeppsson,
J.Falting,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Design and Synthesis of BACE1 Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides (Compound (R)-41)
(pdb code 4b00). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Design and Synthesis of BACE1 Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides (Compound (R)-41), PDB code: 4b00: Fluorine binding site 1 out of 1 in 4b00Go back to Fluorine Binding Sites List in 4b00
Fluorine binding site 1 out
of 1 in the Design and Synthesis of BACE1 Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides (Compound (R)-41)
Mono view Stereo pair view
Reference:
B.M.Swahn,
K.Kolmodin,
S.Karlstrom,
S.Von Berg,
P.Soderman,
J.Holenz,
S.Berg,
J.Lindstrom,
M.Sundstrom,
D.Turek,
J.Kihlstrom,
C.Slivo,
L.Andersson,
D.Pyring,
D.Rotticci,
L.Ohberg,
A.Kers,
K.Bogar,
F.Von Kieseritzky,
M.Bergh,
L.L.Olsson,
J.Janson,
S.Eketjall,
B.Georgievska,
F.Jeppsson,
J.Falting.
Design and Synthesis of Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of Beta-Amyloid Peptides. J. Med. Chem. V. 55 9346 2012.
Page generated: Sun Dec 13 11:59:01 2020
ISSN: ISSN 1520-4804 PubMed: 22924815 DOI: 10.1021/JM3009025 |
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