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Fluorine in PDB 4bcd: Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor
Enzymatic activity of Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor
All present enzymatic activity of Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor:
3.4.21.26;
3.4.21.26;
Protein crystallography data
The structure of Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor, PDB code: 4bcd
was solved by
P.Vanderveken,
V.Fulop,
D.Rea,
M.Gerard,
R.Vanelzen,
J.Joossens,
J.D.Cheng,
V.Baekelandt,
I.Demeester,
A.M.Lambeir,
K.Augustyns,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 55.47 / 1.50 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 70.760, 99.210, 110.950, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.83 / 18.581 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor
(pdb code 4bcd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor, PDB code: 4bcd:
In total only one binding site of Fluorine was determined in the Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor, PDB code: 4bcd:
Fluorine binding site 1 out of 1 in 4bcd
Go back to
Fluorine Binding Sites List in 4bcd
Fluorine binding site 1 out
of 1 in the Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor within 5.0Å range:
|
Reference:
P.Van Der Veken,
V.Fulop,
D.Rea,
M.Gerard,
R.Van Elzen,
J.Joossens,
J.D.Cheng,
V.Baekelandt,
I.De Meester,
A.M.Lambeir,
K.Augustyns.
P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in A Cellular Model of Synucleinopathy. J.Med.Chem. V. 55 9856 2012.
ISSN: ISSN 0022-2623
PubMed: 23121075
DOI: 10.1021/JM301060G
Page generated: Thu Aug 1 00:10:24 2024
ISSN: ISSN 0022-2623
PubMed: 23121075
DOI: 10.1021/JM301060G
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