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Fluorine in PDB 4bcd: Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine InhibitorEnzymatic activity of Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor
All present enzymatic activity of Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor:
3.4.21.26; Protein crystallography data
The structure of Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor, PDB code: 4bcd
was solved by
P.Vanderveken,
V.Fulop,
D.Rea,
M.Gerard,
R.Vanelzen,
J.Joossens,
J.D.Cheng,
V.Baekelandt,
I.Demeester,
A.M.Lambeir,
K.Augustyns,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor
(pdb code 4bcd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor, PDB code: 4bcd: Fluorine binding site 1 out of 1 in 4bcdGo back to Fluorine Binding Sites List in 4bcd
Fluorine binding site 1 out
of 1 in the Prolyl Oligopeptidase From Porcine Brain with A Non- Covalently Bound P2-Substituted N-Acyl-Prolylpyrrolidine Inhibitor
Mono view Stereo pair view
Reference:
P.Van Der Veken,
V.Fulop,
D.Rea,
M.Gerard,
R.Van Elzen,
J.Joossens,
J.D.Cheng,
V.Baekelandt,
I.De Meester,
A.M.Lambeir,
K.Augustyns.
P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in A Cellular Model of Synucleinopathy. J.Med.Chem. V. 55 9856 2012.
Page generated: Sun Dec 13 11:59:18 2020
ISSN: ISSN 0022-2623 PubMed: 23121075 DOI: 10.1021/JM301060G |
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