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Atomistry » Fluorine » PDB 4c6l-4cqj » 4c9x | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4c6l-4cqj » 4c9x » |
Fluorine in PDB 4c9x: Crystal Structure of NUDT1 (MTH1) with S-CrizotinibEnzymatic activity of Crystal Structure of NUDT1 (MTH1) with S-Crizotinib
All present enzymatic activity of Crystal Structure of NUDT1 (MTH1) with S-Crizotinib:
3.6.1.55; 3.6.1.56; Protein crystallography data
The structure of Crystal Structure of NUDT1 (MTH1) with S-Crizotinib, PDB code: 4c9x
was solved by
J.M.Elkins,
E.Salah,
M.Vollmar,
K.Huber,
G.Superti-Furga,
K.R.Abdul Azeez,
T.Krojer,
F.Von Delft,
C.Bountra,
A.Edwards,
S.Knapp,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4c9x:
The structure of Crystal Structure of NUDT1 (MTH1) with S-Crizotinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of NUDT1 (MTH1) with S-Crizotinib
(pdb code 4c9x). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of NUDT1 (MTH1) with S-Crizotinib, PDB code: 4c9x: Fluorine binding site 1 out of 1 in 4c9xGo back to Fluorine Binding Sites List in 4c9x
Fluorine binding site 1 out
of 1 in the Crystal Structure of NUDT1 (MTH1) with S-Crizotinib
Mono view Stereo pair view
Reference:
K.V.M.Huber,
E.Salah,
B.Radic,
M.Gridling,
J.M.Elkins,
A.Stukalov,
A.Jemth,
C.Gokturk,
K.Sanjiv,
K.Stromberg,
T.Pham,
U.W.Berglund,
J.Colinge,
K.L.Bennett,
J.I.Loizou,
T.Helleday,
S.Knapp,
G.Superti-Furga.
Stereospecific Targeting of MTH1 By (S)-Crizotinib As An Anticancer Strategy. Nature V. 508 222 2014.
Page generated: Sun Dec 13 12:00:13 2020
ISSN: ISSN 0028-0836 PubMed: 24695225 DOI: 10.1038/NATURE13194 |
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