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Atomistry » Fluorine » PDB 4c6l-4cqj » 4cka » |
Fluorine in PDB 4cka: Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs)Enzymatic activity of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs)
All present enzymatic activity of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs):
1.14.13.70; Protein crystallography data
The structure of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs), PDB code: 4cka
was solved by
L.Friggeri,
Z.Wawrzak,
S.Tortorella,
G.I.Lepesheva,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4cka:
The structure of Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs)
(pdb code 4cka). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs), PDB code: 4cka: Fluorine binding site 1 out of 1 in 4ckaGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Sterol 14-Alpha Demethylase (CYP51)From Trypanosoma Cruzi in Complex with (S)-1-(4-Fluorophenyl)-2-(1H-Imidazol-1-Yl) Ethyl 4-Isopropylphenylcarbamate (Lfs)
![]() Mono view ![]() Stereo pair view
Reference:
L.Friggeri,
T.Y.Hargrove,
G.Rachakonda,
A.D.Williams,
Z.Wawrzak,
R.Di Santo,
D.De Vita,
M.R.Waterman,
S.Tortorella,
F.Villalta,
G.I.Lepesheva.
Structural Basis For Rational Design of Inhibitors Targeting Trypanosoma Cruzi Sterol 14ALPHA-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition. J.Med.Chem. V. 57 6704 2014.
Page generated: Thu Aug 1 00:44:13 2024
ISSN: ISSN 0022-2623 PubMed: 25033013 DOI: 10.1021/JM500739F |
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