|
Atomistry » Fluorine » PDB 4dbu-4e28 » 4dmy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4dbu-4e28 » 4dmy » |
Fluorine in PDB 4dmy: Cathepsin K InhibitorEnzymatic activity of Cathepsin K Inhibitor
All present enzymatic activity of Cathepsin K Inhibitor:
3.4.22.38; Protein crystallography data
The structure of Cathepsin K Inhibitor, PDB code: 4dmy
was solved by
A.G.Dossetter,
H.Beeley,
J.Bowyer,
C.R.Cook,
J.J.Crawford,
J.E.Finlayson,
N.M.Heron,
C.Heyes,
A.J.Highton,
J.A.Hudson,
P.W.Kenny,
S.Martin,
P.A.Macfaul,
T.M.Mcguire,
P.M.Gutierrez,
A.D.Morley,
J.J.Morris,
K.M.Page,
L.Rosenbrier Ribeiro,
H.Sawney,
S.Steinbacher,
S.Krapp,
A.Jestel,
C.Smith,
M.Vickers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Cathepsin K Inhibitor
(pdb code 4dmy). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cathepsin K Inhibitor, PDB code: 4dmy: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 4dmyGo back to Fluorine Binding Sites List in 4dmy
Fluorine binding site 1 out
of 2 in the Cathepsin K Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 4dmyGo back to Fluorine Binding Sites List in 4dmy
Fluorine binding site 2 out
of 2 in the Cathepsin K Inhibitor
Mono view Stereo pair view
Reference:
A.G.Dossetter,
H.Beeley,
J.Bowyer,
C.R.Cook,
J.J.Crawford,
J.E.Finlayson,
N.M.Heron,
C.Heyes,
A.J.Highton,
J.A.Hudson,
A.Jestel,
P.W.Kenny,
S.Krapp,
S.Martin,
P.A.Macfaul,
T.M.Mcguire,
P.M.Gutierrez,
A.D.Morley,
J.J.Morris,
K.M.Page,
L.R.Ribeiro,
H.Sawney,
S.Steinbacher,
C.Smith,
M.Vickers.
(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-Methoxy-1,3,4, 5-Tetrahydropyrido[4,3-B]Indole-2-Carbonyl) Cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor For the Treatment of Osteoarthritis. J.Med.Chem. V. 55 6363 2012.
Page generated: Sun Dec 13 12:01:30 2020
ISSN: ISSN 0022-2623 PubMed: 22742641 DOI: 10.1021/JM3007257 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |