Fluorine »
PDB 4e3n-4f9m »
4e4x »
Fluorine in PDB 4e4x: Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
Enzymatic activity of Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
All present enzymatic activity of Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor, PDB code: 4e4x
was solved by
W.C.Voegtli,
H.L.Sturgis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.86 / 3.60 |
| Space group | P 41 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 109.000, 109.000, 155.210, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 29.9 / 33.8 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
(pdb code 4e4x). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor, PDB code: 4e4x:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor, PDB code: 4e4x:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 4e4x
Go back to
Fluorine Binding Sites List in 4e4x
Fluorine binding site 1 out
of 4 in the Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 4e4x
Go back to
Fluorine Binding Sites List in 4e4x
Fluorine binding site 2 out
of 4 in the Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 4e4x
Go back to
Fluorine Binding Sites List in 4e4x
Fluorine binding site 3 out
of 4 in the Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 4e4x
Go back to
Fluorine Binding Sites List in 4e4x
Fluorine binding site 4 out
of 4 in the Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of B-Raf Kinase Domain in Complex with A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor within 5.0Å range:
|
Reference:
L.Ren,
K.A.Ahrendt,
J.Grina,
E.R.Laird,
A.J.Buckmelter,
J.D.Hansen,
B.Newhouse,
D.Moreno,
S.Wenglowsky,
V.Dinkel,
S.L.Gloor,
G.Hastings,
S.Rana,
K.Rasor,
T.Risom,
H.L.Sturgis,
W.C.Voegtli,
S.Mathieu.
The Discovery of Potent and Selective Pyridopyrimidin-7-One Based Inhibitors of B-Raf(V600E) Kinase. Bioorg.Med.Chem.Lett. V. 22 3387 2012.
ISSN: ISSN 0960-894X
PubMed: 22534450
DOI: 10.1016/J.BMCL.2012.04.015
Page generated: Thu Aug 1 01:16:34 2024
ISSN: ISSN 0960-894X
PubMed: 22534450
DOI: 10.1016/J.BMCL.2012.04.015
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
