Fluorine in PDB 4ead: Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro- Dideoxyuridine

All present enzymatic activity of Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro- Dideoxyuridine:
2.4.2.4;

The structure of Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro- Dideoxyuridine, PDB code: 4ead was solved by V.I.Timofeev, Y.A.Abramchik, R.S.Esipov, I.P.Kuranova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	16.00 / 1.50
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	129.862, 129.862, 67.656, 90.00, 90.00, 90.00
R / Rfree (%)	14.5 / 19.2

The binding sites of Fluorine atom in the Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro- Dideoxyuridine (pdb code 4ead). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro- Dideoxyuridine, PDB code: 4ead:

Fluorine binding site 1 out of 1 in the Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro- Dideoxyuridine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro- Dideoxyuridine within 5.0Å range: probe atom residue distance (Å) B Occ A:F501 b:35.6 occ:1.00 F2' A:0NP501 0.0 35.6 1.0 C2' A:0NP501 1.4 29.5 1.0 C3' A:0NP501 2.4 34.1 1.0 C1' A:0NP501 2.4 23.7 1.0 N3' A:0NP501 2.5 43.1 1.0 N18 A:0NP501 2.8 42.1 1.0 N1 A:0NP501 3.2 22.0 1.0 O A:HOH909 3.4 36.9 1.0 O4' A:0NP501 3.5 23.7 1.0 N19 A:0NP501 3.5 31.2 1.0 C4' A:0NP501 3.5 29.4 1.0 CG2 A:ILE183 3.5 18.0 1.0 CD1 A:ILE187 3.7 21.9 1.0 C6 A:0NP501 3.8 24.9 1.0 O A:HOH689 3.9 33.9 1.0 C2 A:0NP501 4.0 19.7 1.0 O2 A:0NP501 4.1 20.8 1.0 CG1 A:ILE187 4.2 21.6 1.0 O5' A:0NP501 4.4 34.2 1.0 CG2 A:THR87 4.6 17.8 1.0 O A:THR87 4.6 21.3 1.0 C5' A:0NP501 4.6 31.9 1.0 CB A:THR87 4.6 18.5 1.0 CA A:THR87 4.7 15.7 1.0 CB A:ILE183 4.7 16.2 1.0 CG1 A:ILE183 4.8 16.6 1.0 C5 A:0NP501 4.9 25.9 1.0

V.I.Timofeev, Y.A.Abramchik, R.S.Esipov, I.P.Kuranova. Thymidine Phosphorylase From E.Coli with 3'-Azido-2'-Fluoro-Dideoxyuridine To Be Published.