Fluorine »
PDB 4f9w-4fvx »
4fog »
Fluorine in PDB 4fog: Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid
Enzymatic activity of Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid
All present enzymatic activity of Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid:
2.1.1.45;
2.1.1.45;
Protein crystallography data
The structure of Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid, PDB code: 4fog
was solved by
M.C.M.Reddy,
J.B.Bruning,
W.Harshbarger,
J.C.Sacchettini,
Tb Structuralgenomics Consortium (Tbsgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 42.94 / 2.40 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 184.328, 82.317, 125.980, 90.00, 132.30, 90.00 |
| R / Rfree (%) | 21.1 / 26 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid
(pdb code 4fog). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid, PDB code: 4fog:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid, PDB code: 4fog:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 4fog
Go back to
Fluorine Binding Sites List in 4fog
Fluorine binding site 1 out
of 4 in the Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 4fog
Go back to
Fluorine Binding Sites List in 4fog
Fluorine binding site 2 out
of 4 in the Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 4fog
Go back to
Fluorine Binding Sites List in 4fog
Fluorine binding site 3 out
of 4 in the Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 4fog
Go back to
Fluorine Binding Sites List in 4fog
Fluorine binding site 4 out
of 4 in the Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Mtb Thya in Complex with 5-Fluoro-Dump and 5- Methyltetrahydrofolic Acid within 5.0Å range:
|
Reference:
M.C.M.Reddy,
J.B.Bruning,
J.C.Sacchettini.
Crystal Structure of Binary and Ternary Complexes of Thymidylate Synthase (Thya) From Mycobacterium Tuberculosis: Insights Into the Selectivity and Mode of Inhibition To Be Published.
Page generated: Thu Aug 1 01:38:27 2024
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
