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Atomistry » Fluorine » PDB 4fxq-4goa » 4g16 » |
Fluorine in PDB 4g16: Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-CarbonitrileEnzymatic activity of Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile
All present enzymatic activity of Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile:
2.7.11.1; Protein crystallography data
The structure of Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile, PDB code: 4g16
was solved by
X.Huang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile
(pdb code 4g16). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile, PDB code: 4g16: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4g16Go back to Fluorine Binding Sites List in 4g16
Fluorine binding site 1 out
of 3 in the Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 4g16Go back to Fluorine Binding Sites List in 4g16
Fluorine binding site 2 out
of 3 in the Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 4g16Go back to Fluorine Binding Sites List in 4g16
Fluorine binding site 3 out
of 3 in the Crystal Structure of CK1G3 with 2-[(4-{[3-(Trifluoromethyl)PYRIDIN2- Yl]Oxy}Phenyl)Amino]-1H-Benzimidazole-6-Carbonitrile
Mono view Stereo pair view
Reference:
Z.Hua,
X.Huang,
H.Bregman,
N.Chakka,
E.F.Dimauro,
E.M.Doherty,
J.Goldstein,
H.Gunaydin,
H.Huang,
S.Mercede,
J.Newcomb,
V.F.Patel,
S.M.Turci,
J.Yan,
C.Wilson,
M.W.Martin.
2-Phenylamino-6-Cyano-1H-Benzimidazole-Based Isoform Selective Casein Kinase 1 Gamma (CK1G)Inhibitors Bioorg.Med.Chem.Lett. V. 22 5392 2012.
Page generated: Sun Dec 13 12:02:58 2020
ISSN: ISSN 0960-894X PubMed: 22877629 DOI: 10.1016/J.BMCL.2012.07.046 |
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