Atomistry » Fluorine » PDB 4fxq-4goa » 4gnk
Atomistry »
  Fluorine »
    PDB 4fxq-4goa »
      4gnk »

Fluorine in PDB 4gnk: Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3

Enzymatic activity of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3

All present enzymatic activity of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3:
3.1.4.11;

Protein crystallography data

The structure of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3, PDB code: 4gnk was solved by A.M.Lyon, J.J.G.Tesmer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.99 / 4.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 91.423, 188.845, 293.857, 90.00, 90.00, 90.00
R / Rfree (%) 21.4 / 25.5

Other elements in 4gnk:

The structure of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Aluminium (Al) 2 atoms
Calcium (Ca) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 (pdb code 4gnk). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3, PDB code: 4gnk:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Fluorine binding site 1 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 1 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F402

b:95.6
occ:1.00
 F1 A:ALF402 0.0 95.6 1.0
AL A:ALF402 1.9 93.4 1.0
O3B A:GDP401 2.6 94.1 1.0
F2 A:ALF402 2.6 95.0 1.0
F4 A:ALF402 2.6 95.8 1.0
O A:HOH501 2.6 92.1 1.0
NE2 A:GLN209 2.8 93.7 1.0
N A:GLU49 2.9 0.3 1.0
O1B A:GDP401 3.1 94.2 1.0
PB A:GDP401 3.4 94.1 1.0
CA A:GLY48 3.5 0.0 1.0
CD A:GLN209 3.6 93.1 1.0
F3 A:ALF402 3.7 93.0 1.0
C A:GLY48 3.7 1.0 1.0
OE1 A:GLN209 3.7 89.9 1.0
CA A:GLU49 3.9 0.0 1.0
NH2 A:ARG183 4.0 0.4 1.0
N A:GLY208 4.1 96.2 1.0
CA A:GLY208 4.1 96.4 1.0
NH1 A:ARG183 4.2 0.4 1.0
NZ A:LYS52 4.2 0.9 1.0
O3A A:GDP401 4.4 94.8 1.0
CG A:GLU49 4.4 0.1 1.0
O A:THR47 4.6 0.3 1.0
N A:GLY48 4.6 0.1 1.0
O2B A:GDP401 4.6 93.4 1.0
CZ A:ARG183 4.6 0.2 1.0
N A:GLN209 4.7 97.1 1.0
MG A:MG403 4.7 96.1 1.0
CB A:GLU49 4.7 0.5 1.0
C A:GLY208 4.7 97.1 1.0
CG A:GLN209 4.9 95.3 1.0
O A:HOH502 4.9 98.4 1.0
O A:GLY48 4.9 1.0 1.0
C A:THR47 5.0 0.2 1.0

Fluorine binding site 2 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 2 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F402

b:95.0
occ:1.00
 F2 A:ALF402 0.0 95.0 1.0
AL A:ALF402 1.8 93.4 1.0
F3 A:ALF402 2.6 93.0 1.0
O A:HOH501 2.6 92.1 1.0
F1 A:ALF402 2.6 95.6 1.0
NZ A:LYS52 2.8 0.9 1.0
O3B A:GDP401 2.8 94.1 1.0
O1B A:GDP401 2.9 94.2 1.0
N A:GLY208 3.0 96.2 1.0
PB A:GDP401 3.0 94.1 1.0
CE A:LYS52 3.1 0.8 1.0
O A:HOH503 3.1 96.2 1.0
MG A:MG403 3.4 96.1 1.0
CA A:GLY208 3.4 96.4 1.0
O2B A:GDP401 3.4 93.4 1.0
F4 A:ALF402 3.7 95.8 1.0
C A:GLY207 3.7 97.1 1.0
O A:VAL206 3.7 94.5 1.0
CA A:GLY207 4.0 98.5 1.0
CD A:LYS52 4.5 0.7 1.0
N A:GLU49 4.6 0.3 1.0
O3A A:GDP401 4.6 94.8 1.0
O A:THR47 4.6 0.3 1.0
O A:HOH502 4.6 98.4 1.0
O A:GLY207 4.6 95.9 1.0
C A:VAL206 4.7 95.2 1.0
C A:GLY208 4.7 97.1 1.0
N A:GLY207 4.8 97.2 1.0
CB A:LYS52 4.9 0.8 1.0
O A:THR186 4.9 95.9 1.0
CG A:LYS52 4.9 0.8 1.0
OG1 A:THR186 4.9 0.0 1.0
CB A:THR186 4.9 0.6 1.0
CA A:GLY48 5.0 0.0 1.0

Fluorine binding site 3 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 3 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F402

b:93.0
occ:1.00
 F3 A:ALF402 0.0 93.0 1.0
AL A:ALF402 1.8 93.4 1.0
MG A:MG403 2.0 96.1 1.0
F2 A:ALF402 2.6 95.0 1.0
F4 A:ALF402 2.6 95.8 1.0
O A:HOH501 2.6 92.1 1.0
OG1 A:THR186 2.6 0.0 1.0
O3B A:GDP401 2.6 94.1 1.0
CB A:THR186 2.6 0.6 1.0
N A:THR186 2.7 0.8 1.0
O A:HOH502 2.9 98.4 1.0
O A:HOH503 2.9 96.2 1.0
CA A:THR186 3.0 0.8 1.0
O A:THR186 3.3 95.9 1.0
C A:THR186 3.5 99.8 1.0
PB A:GDP401 3.6 94.1 1.0
O2B A:GDP401 3.6 93.4 1.0
F1 A:ALF402 3.7 95.6 1.0
C A:PRO185 3.9 98.9 1.0
OG A:SER53 3.9 99.0 1.0
CG2 A:THR186 4.1 0.9 1.0
O A:VAL206 4.2 94.5 1.0
CA A:PRO185 4.3 94.6 1.0
CA A:GLY207 4.4 98.5 1.0
O1B A:GDP401 4.4 94.2 1.0
N A:GLY208 4.6 96.2 1.0
N A:THR187 4.7 99.4 1.0
O3A A:GDP401 4.9 94.8 1.0
O A:PRO185 4.9 0.6 1.0
NH1 A:ARG183 4.9 0.4 1.0
C A:GLY207 5.0 97.1 1.0

Fluorine binding site 4 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 4 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F402

b:95.8
occ:1.00
 F4 A:ALF402 0.0 95.8 1.0
AL A:ALF402 1.8 93.4 1.0
O3B A:GDP401 2.4 94.1 1.0
F3 A:ALF402 2.6 93.0 1.0
O A:HOH501 2.6 92.1 1.0
F1 A:ALF402 2.6 95.6 1.0
NH1 A:ARG183 3.0 0.4 1.0
CA A:PRO185 3.1 94.6 1.0
NH2 A:ARG183 3.1 0.4 1.0
N A:THR186 3.1 0.8 1.0
O A:HOH502 3.3 98.4 1.0
CB A:PRO185 3.3 93.4 1.0
CZ A:ARG183 3.5 0.2 1.0
C A:PRO185 3.5 98.9 1.0
F2 A:ALF402 3.7 95.0 1.0
PB A:GDP401 3.9 94.1 1.0
MG A:MG403 3.9 96.1 1.0
O A:THR186 4.0 95.9 1.0
NE2 A:GLN209 4.1 93.7 1.0
OE1 A:GLN209 4.2 89.9 1.0
CA A:THR186 4.3 0.8 1.0
N A:PRO185 4.4 93.1 1.0
O1B A:GDP401 4.6 94.2 1.0
OG1 A:THR186 4.6 0.0 1.0
O2A A:GDP401 4.6 94.2 1.0
CD A:GLN209 4.6 93.1 1.0
O3A A:GDP401 4.6 94.8 1.0
C A:THR186 4.6 99.8 1.0
O A:PRO185 4.7 0.6 1.0
NE A:ARG183 4.7 0.3 1.0
O2B A:GDP401 4.7 93.4 1.0
CB A:THR186 4.7 0.6 1.0
CG A:PRO185 4.8 93.8 1.0
O A:VAL184 4.8 92.2 1.0

Fluorine binding site 5 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 5 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F402

b:82.8
occ:1.00
 F1 C:ALF402 0.0 82.8 1.0
AL C:ALF402 1.8 82.4 1.0
O3B C:GDP401 2.5 87.1 1.0
F2 C:ALF402 2.6 85.1 1.0
F4 C:ALF402 2.6 83.8 1.0
O C:HOH501 2.6 82.4 1.0
NE2 C:GLN209 2.7 95.3 1.0
N C:GLU49 2.9 0.7 1.0
CA C:GLY48 3.4 0.2 1.0
CD C:GLN209 3.5 94.4 1.0
O1B C:GDP401 3.5 86.4 1.0
PB C:GDP401 3.5 87.5 1.0
OE1 C:GLN209 3.5 92.1 1.0
C C:GLY48 3.6 0.6 1.0
F3 C:ALF402 3.7 85.3 1.0
CA C:GLU49 3.9 0.5 1.0
NH2 C:ARG183 3.9 98.1 1.0
NH1 C:ARG183 4.1 98.0 1.0
N C:GLY208 4.1 93.1 1.0
CA C:GLY208 4.2 94.8 1.0
NZ C:LYS52 4.3 0.2 1.0
CG C:GLU49 4.3 0.8 1.0
O C:THR47 4.4 0.8 1.0
CZ C:ARG183 4.5 98.0 1.0
N C:GLY48 4.5 0.5 1.0
O3A C:GDP401 4.6 86.5 1.0
C C:GLY208 4.6 97.5 1.0
CB C:GLU49 4.7 0.1 1.0
O2B C:GDP401 4.7 87.0 1.0
N C:GLN209 4.7 97.1 1.0
O C:GLY48 4.8 0.3 1.0
CG C:GLN209 4.8 95.6 1.0
C C:THR47 4.9 0.4 1.0
MG C:MG403 5.0 87.5 1.0

Fluorine binding site 6 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 6 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F402

b:85.1
occ:1.00
 F2 C:ALF402 0.0 85.1 1.0
AL C:ALF402 1.8 82.4 1.0
F3 C:ALF402 2.6 85.3 1.0
O C:HOH501 2.6 82.4 1.0
F1 C:ALF402 2.6 82.8 1.0
NZ C:LYS52 2.6 0.2 1.0
O3B C:GDP401 2.9 87.1 1.0
N C:GLY208 2.9 93.1 1.0
O1B C:GDP401 3.0 86.4 1.0
PB C:GDP401 3.1 87.5 1.0
CE C:LYS52 3.1 0.9 1.0
O C:HOH503 3.2 89.9 1.0
CA C:GLY208 3.3 94.8 1.0
O2B C:GDP401 3.4 87.0 1.0
MG C:MG403 3.5 87.5 1.0
C C:GLY207 3.6 91.0 1.0
F4 C:ALF402 3.7 83.8 1.0
O C:VAL206 3.8 84.1 1.0
CA C:GLY207 3.9 89.8 1.0
O C:THR47 4.4 0.8 1.0
N C:GLU49 4.5 0.7 1.0
CD C:LYS52 4.5 0.7 1.0
O C:GLY207 4.5 91.7 1.0
C C:GLY208 4.6 97.5 1.0
O3A C:GDP401 4.7 86.5 1.0
C C:VAL206 4.7 86.3 1.0
N C:GLY207 4.8 87.8 1.0
CA C:GLY48 4.9 0.2 1.0
O C:HOH502 4.9 85.1 1.0
NE2 C:GLN209 4.9 95.3 1.0
OE1 C:GLN209 4.9 92.1 1.0
CB C:THR186 4.9 96.8 1.0
OG1 C:THR186 4.9 99.5 1.0
CG C:LYS52 4.9 0.9 1.0
N C:GLN209 4.9 97.1 1.0
CB C:LYS52 4.9 0.3 1.0

Fluorine binding site 7 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 7 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F402

b:85.3
occ:1.00
 F3 C:ALF402 0.0 85.3 1.0
AL C:ALF402 1.8 82.4 1.0
MG C:MG403 2.0 87.5 1.0
F4 C:ALF402 2.6 83.8 1.0
O C:HOH501 2.6 82.4 1.0
F2 C:ALF402 2.6 85.1 1.0
O3B C:GDP401 2.7 87.1 1.0
OG1 C:THR186 2.7 99.5 1.0
N C:THR186 2.7 92.7 1.0
CB C:THR186 2.8 96.8 1.0
O C:HOH503 2.9 89.9 1.0
O C:HOH502 2.9 85.1 1.0
O2B C:GDP401 3.1 87.0 1.0
CA C:THR186 3.2 94.5 1.0
PB C:GDP401 3.4 87.5 1.0
O C:THR186 3.6 91.8 1.0
F1 C:ALF402 3.7 82.8 1.0
C C:THR186 3.8 93.5 1.0
C C:PRO185 3.8 91.9 1.0
OG C:SER53 3.9 96.9 1.0
CA C:PRO185 4.2 90.8 1.0
CG2 C:THR186 4.3 97.9 1.0
O C:VAL206 4.3 84.1 1.0
O1B C:GDP401 4.3 86.4 1.0
CA C:GLY207 4.5 89.8 1.0
NH1 C:ARG183 4.7 98.0 1.0
N C:GLY208 4.7 93.1 1.0
O3A C:GDP401 4.7 86.5 1.0
O2A C:GDP401 4.8 83.0 1.0
O C:PRO185 4.9 92.9 1.0
CB C:PRO185 4.9 89.9 1.0
NZ C:LYS52 5.0 0.2 1.0
N C:THR187 5.0 94.8 1.0

Fluorine binding site 8 out of 8 in 4gnk

Go back to Fluorine Binding Sites List in 4gnk
Fluorine binding site 8 out of 8 in the Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Crystal Structure of Galphaq in Complex with Full-Length Human PLCBETA3 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F402

b:83.8
occ:1.00
 F4 C:ALF402 0.0 83.8 1.0
AL C:ALF402 1.8 82.4 1.0
O3B C:GDP401 2.3 87.1 1.0
F3 C:ALF402 2.6 85.3 1.0
O C:HOH501 2.6 82.4 1.0
F1 C:ALF402 2.6 82.8 1.0
NH1 C:ARG183 2.8 98.0 1.0
NH2 C:ARG183 2.9 98.1 1.0
CA C:PRO185 3.1 90.8 1.0
CZ C:ARG183 3.2 98.0 1.0
CB C:PRO185 3.3 89.9 1.0
N C:THR186 3.4 92.7 1.0
O C:HOH502 3.6 85.1 1.0
C C:PRO185 3.7 91.9 1.0
F2 C:ALF402 3.7 85.1 1.0
PB C:GDP401 3.8 87.5 1.0
MG C:MG403 4.0 87.5 1.0
OE1 C:GLN209 4.2 92.1 1.0
NE2 C:GLN209 4.2 95.3 1.0
O C:THR186 4.4 91.8 1.0
N C:PRO185 4.4 91.4 1.0
NE C:ARG183 4.4 98.9 1.0
O2B C:GDP401 4.4 87.0 1.0
CA C:THR186 4.6 94.5 1.0
O3A C:GDP401 4.6 86.5 1.0
O2A C:GDP401 4.6 83.0 1.0
CD C:GLN209 4.7 94.4 1.0
O1B C:GDP401 4.7 86.4 1.0
CG C:PRO185 4.7 90.4 1.0
O C:PRO185 4.8 92.9 1.0
OG1 C:THR186 4.8 99.5 1.0
O C:VAL184 4.9 96.2 1.0
N C:GLU49 5.0 0.7 1.0
CB C:THR186 5.0 96.8 1.0
C C:THR186 5.0 93.5 1.0

Reference:

A.M.Lyon, S.Dutta, C.A.Boguth, G.Skiniotis, J.J.Tesmer. Full-Length G Alpha (Q)-Phospholipase C-Beta 3 Structure Reveals Interfaces of the C-Terminal Coiled-Coil Domain. Nat.Struct.Mol.Biol. V. 20 355 2013.
ISSN: ISSN 1545-9993
PubMed: 23377541
DOI: 10.1038/NSMB.2497
Page generated: Thu Aug 1 01:53:16 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy