Fluorine in PDB 4gpb: Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B

All present enzymatic activity of Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B:
2.4.1.1;

The structure of Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B, PDB code: 4gpb was solved by J.L.Martin, L.N.Johnson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.30
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	128.500, 128.500, 116.300, 90.00, 90.00, 90.00
R / Rfree (%)	18 / n/a

The binding sites of Fluorine atom in the Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B (pdb code 4gpb). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B, PDB code: 4gpb:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B within 5.0Å range: probe atom residue distance (Å) B Occ A:F900 b:15.5 occ:1.00 F2 A:GFP900 0.0 15.5 1.0 C2 A:GFP900 1.4 19.7 1.0 C3 A:GFP900 2.4 25.1 1.0 C1 A:GFP900 2.5 25.1 1.0 O1 A:GFP900 2.9 30.5 1.0 O3 A:GFP900 2.9 28.3 1.0 OH A:TYR573 2.9 20.5 1.0 O A:HOH1452 3.2 38.4 1.0 OE1 A:GLU672 3.3 34.6 1.0 ND2 A:ASN284 3.3 66.4 1.0 O1P A:GFP900 3.4 30.1 1.0 OD1 A:ASN284 3.7 69.4 1.0 O5 A:GFP900 3.7 22.2 1.0 P A:GFP900 3.8 28.8 1.0 C4 A:GFP900 3.8 24.5 1.0 CG A:ASN284 4.0 69.5 1.0 CZ A:TYR573 4.2 23.2 1.0 C5 A:GFP900 4.3 24.0 1.0 O A:HIS377 4.3 24.3 1.0 NZ A:LYS574 4.4 31.1 1.0 O2P A:GFP900 4.5 33.3 1.0 CD A:GLU672 4.5 30.0 1.0 N A:ALA673 4.8 22.2 1.0 O4 A:GFP900 4.9 19.5 1.0 CE2 A:TYR573 5.0 23.2 1.0

Fluorine binding site 2 out of 2 in the Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Comparison of the Binding of Glucose and Glucose-1-Phosphate Derivatives to T-State Glycogen Phosphorylase B within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:20.9 occ:1.00 F2 A:GFP901 0.0 20.9 1.0 C2 A:GFP901 1.4 85.7 1.0 C3 A:GFP901 2.4 87.9 1.0 C1 A:GFP901 2.5 83.2 1.0 O1P A:GFP901 2.7 63.8 1.0 O3 A:GFP901 2.8 86.0 1.0 CZ A:PHE196 3.1 60.9 1.0 O1 A:GFP901 3.1 71.9 1.0 P A:GFP901 3.5 59.6 1.0 C4 A:GFP901 3.7 90.1 1.0 O5 A:GFP901 3.7 87.9 1.0 CE2 A:PHE196 3.9 57.6 1.0 CE1 A:PHE196 4.0 60.1 1.0 O3P A:GFP901 4.1 62.5 1.0 C5 A:GFP901 4.3 91.1 1.0 NH1 A:ARG309 4.7 37.5 1.0 O2P A:GFP901 4.8 61.1 1.0 O4 A:GFP901 4.8 89.3 1.0

J.L.Martin, L.N.Johnson, S.G.Withers. Comparison of the Binding of Glucose and Glucose 1-Phosphate Derivatives to T-State Glycogen Phosphorylase B. Biochemistry V. 29 10745 1990.
ISSN: ISSN 0006-2960
PubMed: 2125493
DOI: 10.1021/BI00500A005