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Fluorine in PDB 4hn4: Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site
Enzymatic activity of Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site
All present enzymatic activity of Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site:
4.2.1.20;
4.2.1.20;
Protein crystallography data
The structure of Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site, PDB code: 4hn4
was solved by
E.Hilario,
D.Niks,
M.F.Dunn,
L.J.Mueller,
L.Fan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 28.59 / 1.64 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 183.970, 59.720, 67.400, 90.00, 94.69, 90.00 |
| R / Rfree (%) | 14.8 / 20 |
Other elements in 4hn4:
The structure of Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site also contains other interesting chemical elements:
| Caesium | (Cs) | 3 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site
(pdb code 4hn4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site, PDB code: 4hn4:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site, PDB code: 4hn4:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 4hn4
Go back to
Fluorine Binding Sites List in 4hn4
Fluorine binding site 1 out
of 3 in the Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 4hn4
Go back to
Fluorine Binding Sites List in 4hn4
Fluorine binding site 2 out
of 3 in the Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 4hn4
Go back to
Fluorine Binding Sites List in 4hn4
Fluorine binding site 3 out
of 3 in the Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Tryptophan Synthase in Complex with Alpha Aminoacrylate E(A-A) Form and the F9 Inhibitor in the Alpha Site within 5.0Å range:
|
Reference:
D.Niks,
E.Hilario,
A.Dierkers,
H.Ngo,
D.Borchardt,
T.J.Neubauer,
L.Fan,
L.J.Mueller,
M.F.Dunn.
Allostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence For Two Subunit Conformations and Four Quaternary States. Biochemistry V. 52 6396 2013.
ISSN: ISSN 0006-2960
PubMed: 23952479
DOI: 10.1021/BI400795E
Page generated: Thu Aug 1 02:05:59 2024
ISSN: ISSN 0006-2960
PubMed: 23952479
DOI: 10.1021/BI400795E
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