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Atomistry » Fluorine » PDB 4hxn-4ijh » 4i22 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4hxn-4ijh » 4i22 » |
Fluorine in PDB 4i22: Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with GefitinibEnzymatic activity of Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with Gefitinib
All present enzymatic activity of Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with Gefitinib:
2.7.10.1; Protein crystallography data
The structure of Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with Gefitinib, PDB code: 4i22
was solved by
K.S.Gajiwala,
J.Feng,
R.Ferre,
K.Ryan,
O.Brodsky,
A.Stewart,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4i22:
The structure of Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with Gefitinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with Gefitinib
(pdb code 4i22). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with Gefitinib, PDB code: 4i22: Fluorine binding site 1 out of 1 in 4i22Go back to Fluorine Binding Sites List in 4i22
Fluorine binding site 1 out
of 1 in the Structure of the Monomeric (V948R)Gefitinib/Erlotinib Resistant Double Mutant (L858R+T790M) Egfr Kinase Domain Co-Crystallized with Gefitinib
Mono view Stereo pair view
Reference:
K.S.Gajiwala,
J.Feng,
R.Ferre,
K.Ryan,
O.Brodsky,
S.Weinrich,
J.C.Kath,
A.Stewart.
Insights Into the Aberrant Activity of Mutant Egfr Kinase Domain and Drug Recognition. Structure V. 21 209 2013.
Page generated: Sun Dec 13 12:04:09 2020
ISSN: ISSN 0969-2126 PubMed: 23273428 DOI: 10.1016/J.STR.2012.11.014 |
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