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Atomistry » Fluorine » PDB 4j0v-4jps » 4jps » |
Fluorine in PDB 4jps: Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective InhibitorsEnzymatic activity of Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
All present enzymatic activity of Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors:
2.7.1.153; 2.7.11.1; Protein crystallography data
The structure of Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors, PDB code: 4jps
was solved by
M.S.Knapp,
R.A.Elling,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
(pdb code 4jps). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors, PDB code: 4jps: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4jpsGo back to![]() ![]()
Fluorine binding site 1 out
of 3 in the Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 4jpsGo back to![]() ![]()
Fluorine binding site 2 out
of 3 in the Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 4jpsGo back to![]() ![]()
Fluorine binding site 3 out
of 3 in the Co-Crystal Structures of the Lipid Kinase PI3K Alpha with Pan and Isoform Selective Inhibitors
![]() Mono view ![]() Stereo pair view
Reference:
P.Furet,
V.Guagnano,
R.A.Fairhurst,
P.Imbach-Weese,
I.Bruce,
M.Knapp,
C.Fritsch,
F.Blasco,
J.Blanz,
R.Aichholz,
J.Hamon,
D.Fabbro,
G.Caravatti.
Discovery of Nvp-BYL719 A Potent and Selective Phosphatidylinositol-3 Kinase Alpha Inhibitor Selected For Clinical Evaluation. Bioorg.Med.Chem.Lett. V. 23 3741 2013.
Page generated: Thu Aug 1 02:56:49 2024
ISSN: ISSN 0960-894X PubMed: 23726034 DOI: 10.1016/J.BMCL.2013.05.007 |
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