Fluorine »
PDB 4jq2-4kbi »
4jsi »
Fluorine in PDB 4jsi: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine
Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine
All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine:
1.14.13.39;
1.14.13.39;
Protein crystallography data
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine, PDB code: 4jsi
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.70 / 2.09 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.597, 110.778, 164.565, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.3 / 24.1 |
Other elements in 4jsi:
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine also contains other interesting chemical elements:
| Iron | (Fe) | 2 atoms |
| Zinc | (Zn) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine
(pdb code 4jsi). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine, PDB code: 4jsi:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine, PDB code: 4jsi:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 4jsi
Go back to
Fluorine Binding Sites List in 4jsi
Fluorine binding site 1 out
of 2 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 4jsi
Go back to
Fluorine Binding Sites List in 4jsi
Fluorine binding site 2 out
of 2 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-((3-(((3-Fluorophenethyl)Amino)Methyl)Phenoxy)Methyl)-4- Methylpyridin-2-Amine within 5.0Å range:
|
Reference:
Q.Jing,
H.Li,
J.Fang,
L.J.Roman,
P.Martasek,
T.L.Poulos,
R.B.Silverman.
In Search of Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase with More Simple Structures. Bioorg.Med.Chem. V. 21 5323 2013.
ISSN: ISSN 0968-0896
PubMed: 23867386
DOI: 10.1016/J.BMC.2013.06.014
Page generated: Thu Aug 1 02:58:35 2024
ISSN: ISSN 0968-0896
PubMed: 23867386
DOI: 10.1016/J.BMC.2013.06.014
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
