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Atomistry » Fluorine » PDB 4jq2-4kbi » 4k0y » |
Fluorine in PDB 4k0y: Structure of Pim-1 Kinase Bound to N-(4-Fluorophenyl)-7-Hydroxy-5- (Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-CarboxamideEnzymatic activity of Structure of Pim-1 Kinase Bound to N-(4-Fluorophenyl)-7-Hydroxy-5- (Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide
All present enzymatic activity of Structure of Pim-1 Kinase Bound to N-(4-Fluorophenyl)-7-Hydroxy-5- (Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide:
2.7.11.1; Protein crystallography data
The structure of Structure of Pim-1 Kinase Bound to N-(4-Fluorophenyl)-7-Hydroxy-5- (Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide, PDB code: 4k0y
was solved by
J.M.Murray,
H.Wallweber,
M.Steffek,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Pim-1 Kinase Bound to N-(4-Fluorophenyl)-7-Hydroxy-5- (Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide
(pdb code 4k0y). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Pim-1 Kinase Bound to N-(4-Fluorophenyl)-7-Hydroxy-5- (Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide, PDB code: 4k0y: Fluorine binding site 1 out of 1 in 4k0yGo back to Fluorine Binding Sites List in 4k0y
Fluorine binding site 1 out
of 1 in the Structure of Pim-1 Kinase Bound to N-(4-Fluorophenyl)-7-Hydroxy-5- (Piperidin-4-Yl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxamide
Mono view Stereo pair view
Reference:
X.Wang,
S.Magnuson,
R.Pastor,
E.Fan,
H.Hu,
V.Tsui,
W.Deng,
J.Murray,
M.Steffek,
H.Wallweber,
J.Moffat,
J.Drummond,
G.Chan,
E.Harstad,
A.J.Ebens.
Discovery of Novel Pyrazolo[1,5-A]Pyrimidines As Potent Pan-Pim Inhibitors By Structure- and Property-Based Drug Design. Bioorg.Med.Chem.Lett. V. 23 3149 2013.
Page generated: Sun Dec 13 12:05:55 2020
ISSN: ISSN 0960-894X PubMed: 23623490 DOI: 10.1016/J.BMCL.2013.04.020 |
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