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Atomistry » Fluorine » PDB 4kbk-4l3l » 4kfo | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4kbk-4l3l » 4kfo » |
Fluorine in PDB 4kfo: Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) InhibitorsEnzymatic activity of Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
All present enzymatic activity of Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors:
2.4.2.12; Protein crystallography data
The structure of Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors, PDB code: 4kfo
was solved by
X.Zheng,
P.Bauer,
T.Baumeister,
A.J.Buckmelter,
M.Caligiuri,
K.H.Clodfelter,
B.Han,
Y.Ho,
N.Kley,
J.Lin,
D.J.Reynolds,
G.Sharma,
C.C.Smith,
Z.Wang,
P.S.Dragovich,
J.Gunzner-Tosteb,
B.M.Liederer,
J.Ly,
T.O'brien,
A.Oh,
L.Wang,
W.Wang,
Y.Xiao,
M.Zak,
G.Zhao,
P.Yuen,
K.W.Bair,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
(pdb code 4kfo). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors, PDB code: 4kfo: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 4kfoGo back to Fluorine Binding Sites List in 4kfo
Fluorine binding site 1 out
of 4 in the Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 4kfoGo back to Fluorine Binding Sites List in 4kfo
Fluorine binding site 2 out
of 4 in the Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 4kfoGo back to Fluorine Binding Sites List in 4kfo
Fluorine binding site 3 out
of 4 in the Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 4kfoGo back to Fluorine Binding Sites List in 4kfo
Fluorine binding site 4 out
of 4 in the Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Mono view Stereo pair view
Reference:
X.Zheng,
P.Bauer,
T.Baumeister,
A.J.Buckmelter,
M.Caligiuri,
K.H.Clodfelter,
B.Han,
Y.C.Ho,
N.Kley,
J.Lin,
D.J.Reynolds,
G.Sharma,
C.C.Smith,
Z.Wang,
P.S.Dragovich,
A.Oh,
W.Wang,
M.Zak,
J.Gunzner-Toste,
G.Zhao,
P.W.Yuen,
K.W.Bair.
Structure-Based Identification of Ureas As Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors. J.Med.Chem. V. 56 4921 2013.
Page generated: Thu Aug 1 03:12:41 2024
ISSN: ISSN 0022-2623 PubMed: 23617784 DOI: 10.1021/JM400186H |
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