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Fluorine in PDB 4kh2: Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride
Enzymatic activity of Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride
All present enzymatic activity of Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride:
3.2.1.76;
3.2.1.76;
Protein crystallography data
The structure of Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride, PDB code: 4kh2
was solved by
H.Bie,
J.Yin,
X.He,
A.R.Kermode,
E.D.Goddard-Borger,
S.G.Withers,
M.N.G.James,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 41.72 / 2.36 |
| Space group | H 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 258.839, 258.839, 71.362, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 22 / 26.1 |
Other elements in 4kh2:
The structure of Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride
(pdb code 4kh2). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride, PDB code: 4kh2:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride, PDB code: 4kh2:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 4kh2
Go back to
Fluorine Binding Sites List in 4kh2
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 4kh2
Go back to
Fluorine Binding Sites List in 4kh2
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human Alpha-L-Iduronidase Complex with 2-Deoxy-2- Fluoro-Alpha-L-Idopyranosyluronic Acid Fluoride within 5.0Å range:
|
Reference:
H.Bie,
J.Yin,
X.He,
A.R.Kermode,
E.D.Goddard-Borger,
S.G.Withers,
M.N.James.
Insights Into Mucopolysaccharidosis I From the Structure and Action of Alpha-L-Iduronidase. Nat.Chem.Biol. V. 9 739 2013.
ISSN: ISSN 1552-4450
PubMed: 24036510
DOI: 10.1038/NCHEMBIO.1357
Page generated: Thu Aug 1 03:12:41 2024
ISSN: ISSN 1552-4450
PubMed: 24036510
DOI: 10.1038/NCHEMBIO.1357
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