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Atomistry » Fluorine » PDB 4kbk-4l3l » 4khr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4kbk-4l3l » 4khr » |
Fluorine in PDB 4khr: Hcv NS5B GT1A C316Y with GSK5852Enzymatic activity of Hcv NS5B GT1A C316Y with GSK5852
All present enzymatic activity of Hcv NS5B GT1A C316Y with GSK5852:
2.7.7.48; Protein crystallography data
The structure of Hcv NS5B GT1A C316Y with GSK5852, PDB code: 4khr
was solved by
S.P.Williams,
K.M.Kahler,
J.B.Shotwell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hcv NS5B GT1A C316Y with GSK5852
(pdb code 4khr). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Hcv NS5B GT1A C316Y with GSK5852, PDB code: 4khr: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 4khrGo back to Fluorine Binding Sites List in 4khr
Fluorine binding site 1 out
of 2 in the Hcv NS5B GT1A C316Y with GSK5852
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 4khrGo back to Fluorine Binding Sites List in 4khr
Fluorine binding site 2 out
of 2 in the Hcv NS5B GT1A C316Y with GSK5852
Mono view Stereo pair view
Reference:
A.Maynard,
R.M.Crosby,
B.Ellis,
R.Hamatake,
Z.Hong,
B.A.Johns,
K.M.Kahler,
C.Koble,
A.Leivers,
M.R.Leivers,
A.Mathis,
A.J.Peat,
J.J.Pouliot,
C.D.Roberts,
V.Samano,
R.M.Schmidt,
G.K.Smith,
A.Spaltenstein,
E.L.Stewart,
P.Thommes,
E.M.Turner,
C.Voitenleitner,
J.T.Walker,
G.Waitt,
J.Weatherhead,
K.Weaver,
S.Williams,
L.Wright,
Z.Z.Xiong,
D.Haigh,
J.B.Shotwell.
Discovery of A Potent Boronic Acid Derived Inhibitor of the Hcv Rna-Dependent Rna Polymerase. J.Med.Chem. V. 57 1902 2014.
Page generated: Sun Dec 13 12:06:20 2020
ISSN: ISSN 0022-2623 PubMed: 23672667 DOI: 10.1021/JM400317W |
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