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Atomistry » Fluorine » PDB 4kbk-4l3l » 4kn6 » |
Fluorine in PDB 4kn6: Crystal Structure of Human Hypoxanthine-Guanine Phosphoribosyltransferase in Complex with 6-Fluoro-3-Hydroxy-2- Pyrazinecarboxamide (T-705) Ribose-5'-MonophosphateEnzymatic activity of Crystal Structure of Human Hypoxanthine-Guanine Phosphoribosyltransferase in Complex with 6-Fluoro-3-Hydroxy-2- Pyrazinecarboxamide (T-705) Ribose-5'-Monophosphate
All present enzymatic activity of Crystal Structure of Human Hypoxanthine-Guanine Phosphoribosyltransferase in Complex with 6-Fluoro-3-Hydroxy-2- Pyrazinecarboxamide (T-705) Ribose-5'-Monophosphate:
2.4.2.8; Protein crystallography data
The structure of Crystal Structure of Human Hypoxanthine-Guanine Phosphoribosyltransferase in Complex with 6-Fluoro-3-Hydroxy-2- Pyrazinecarboxamide (T-705) Ribose-5'-Monophosphate, PDB code: 4kn6
was solved by
L.Naesens,
L.Guddat,
D.Keough,
A.B.P.Van Kuilenburg,
J.Meijer,
J.Vandevoorde,
J.Balzarini,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Hypoxanthine-Guanine Phosphoribosyltransferase in Complex with 6-Fluoro-3-Hydroxy-2- Pyrazinecarboxamide (T-705) Ribose-5'-Monophosphate
(pdb code 4kn6). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Human Hypoxanthine-Guanine Phosphoribosyltransferase in Complex with 6-Fluoro-3-Hydroxy-2- Pyrazinecarboxamide (T-705) Ribose-5'-Monophosphate, PDB code: 4kn6: Fluorine binding site 1 out of 1 in 4kn6Go back to Fluorine Binding Sites List in 4kn6
Fluorine binding site 1 out
of 1 in the Crystal Structure of Human Hypoxanthine-Guanine Phosphoribosyltransferase in Complex with 6-Fluoro-3-Hydroxy-2- Pyrazinecarboxamide (T-705) Ribose-5'-Monophosphate
Mono view Stereo pair view
Reference:
L.Naesens,
L.W.Guddat,
D.T.Keough,
A.B.Van Kuilenburg,
J.Meijer,
J.Vande Voorde,
J.Balzarini.
Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (Favipiravir). Mol.Pharmacol. V. 84 615 2013.
Page generated: Sun Dec 13 12:06:26 2020
ISSN: ISSN 0026-895X PubMed: 23907213 DOI: 10.1124/MOL.113.087247 |
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