Fluorine in PDB 4l45: Crystal Structures of Human P70S6K1-T389E

The structure of Crystal Structures of Human P70S6K1-T389E, PDB code: 4l45 was solved by J.Wang, C.Zhong, J.Ding, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.54 / 2.90
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	81.191, 81.191, 110.744, 90.00, 90.00, 120.00
R / Rfree (%)	23.2 / 28.7

The binding sites of Fluorine atom in the Crystal Structures of Human P70S6K1-T389E (pdb code 4l45). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structures of Human P70S6K1-T389E, PDB code: 4l45:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Crystal Structures of Human P70S6K1-T389E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structures of Human P70S6K1-T389E within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:0.7 occ:1.00 FAB A:5FI401 0.0 0.7 1.0 CBB A:5FI401 1.3 0.4 1.0 FAC A:5FI401 2.2 0.8 1.0 FAD A:5FI401 2.2 0.6 1.0 CAU A:5FI401 2.3 0.3 1.0 CAE A:5FI401 2.8 99.2 1.0 N A:GLY80 3.0 65.3 1.0 CD2 A:LEU102 3.0 57.4 1.0 CA A:GLY80 3.3 64.2 1.0 C A:GLY80 3.4 60.6 1.0 CAI A:5FI401 3.5 93.7 1.0 O A:GLY80 3.5 62.1 1.0 C A:TYR79 3.7 64.4 1.0 N A:LYS81 4.0 55.3 1.0 CB A:TYR79 4.1 62.6 1.0 CAF A:5FI401 4.1 96.8 1.0 CA A:TYR79 4.3 63.2 1.0 O A:TYR79 4.4 66.8 1.0 O A:VAL101 4.4 48.6 1.0 N A:TYR79 4.5 61.3 1.0 CD A:LYS100 4.5 53.7 1.0 CG A:LEU102 4.5 54.7 1.0 CAX A:5FI401 4.6 91.4 1.0 CG A:LYS100 4.7 48.5 1.0 CA A:LYS81 4.8 50.7 1.0 CAY A:5FI401 4.9 92.4 1.0 O A:LYS81 5.0 45.4 1.0

Fluorine binding site 2 out of 3 in the Crystal Structures of Human P70S6K1-T389E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structures of Human P70S6K1-T389E within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:0.8 occ:1.00 FAC A:5FI401 0.0 0.8 1.0 CBB A:5FI401 1.3 0.4 1.0 FAB A:5FI401 2.2 0.7 1.0 FAD A:5FI401 2.2 0.6 1.0 CAU A:5FI401 2.3 0.3 1.0 CAE A:5FI401 3.1 99.2 1.0 CAI A:5FI401 3.3 93.7 1.0 CB A:TYR79 3.6 62.6 1.0 O A:CYS217 3.8 91.4 1.0 N A:TYR79 3.8 61.3 1.0 N A:GLY80 3.9 65.3 1.0 CA A:TYR79 4.0 63.2 1.0 C A:CYS217 4.1 91.2 1.0 N A:LYS218 4.1 92.7 1.0 CD2 A:TYR79 4.2 65.2 1.0 CA A:LYS218 4.2 96.0 1.0 CB A:LEU216 4.2 72.0 1.0 C A:TYR79 4.3 64.4 1.0 CAF A:5FI401 4.3 96.8 1.0 CG A:TYR79 4.4 63.6 1.0 CAX A:5FI401 4.5 91.4 1.0 CD2 A:LEU102 4.6 57.4 1.0 N A:GLY78 4.6 62.9 1.0 C A:LEU216 4.6 77.4 1.0 O A:GLY80 4.6 62.1 1.0 O A:LEU216 4.7 78.0 1.0 CA A:GLY77 4.7 64.2 1.0 CA A:GLY80 4.7 64.2 1.0 N A:CYS217 4.8 82.3 1.0 C A:GLY77 4.8 64.1 1.0 CB A:LYS218 4.9 92.8 1.0 CAY A:5FI401 4.9 92.4 1.0 C A:GLY80 4.9 60.6 1.0 CD1 A:LEU216 5.0 73.7 1.0 C A:GLY78 5.0 61.1 1.0

Fluorine binding site 3 out of 3 in the Crystal Structures of Human P70S6K1-T389E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structures of Human P70S6K1-T389E within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:0.6 occ:1.00 FAD A:5FI401 0.0 0.6 1.0 CBB A:5FI401 1.3 0.4 1.0 FAB A:5FI401 2.2 0.7 1.0 FAC A:5FI401 2.2 0.8 1.0 CAU A:5FI401 2.4 0.3 1.0 CAI A:5FI401 2.7 93.7 1.0 CD2 A:LEU102 3.3 57.4 1.0 CAE A:5FI401 3.6 99.2 1.0 CD A:LYS100 3.7 53.7 1.0 CB A:LEU216 4.0 72.0 1.0 CAX A:5FI401 4.1 91.4 1.0 O A:LEU216 4.2 78.0 1.0 NZ A:LYS100 4.4 62.0 1.0 CG A:LYS100 4.4 48.5 1.0 C A:LEU216 4.4 77.4 1.0 CE A:LYS100 4.5 57.8 1.0 CD1 A:LEU216 4.5 73.7 1.0 CA A:LEU216 4.6 74.0 1.0 N A:LEU216 4.6 68.4 1.0 CG A:LEU102 4.7 54.7 1.0 CB A:TYR79 4.7 62.6 1.0 CAF A:5FI401 4.8 96.8 1.0 CD1 A:LEU102 4.8 53.9 1.0 CG A:LEU216 4.9 73.9 1.0 CAY A:5FI401 4.9 92.4 1.0 N A:GLY80 5.0 65.3 1.0

J.Wang, C.Zhong, F.Wang, F.Qu, J.Ding. Crystal Structures of S6K1 Provide Insights Into the Regulation Mechanism of S6K1 By the Hydrophobic Motif Biochem.J. V. 454 39 2013.
ISSN: ISSN 0264-6021
PubMed: 23731517
DOI: 10.1042/BJ20121863