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Fluorine in PDB 4loo: Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form)

Enzymatic activity of Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form)

All present enzymatic activity of Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form):
2.7.11.24;

Protein crystallography data

The structure of Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form), PDB code: 4loo was solved by A.Chaikuad, G.F.Denicola, T.Krojer, C.K.Allerston, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, M.S.Marber, S.Knapp, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.11 / 1.95
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 43.340, 73.580, 59.190, 90.00, 91.15, 90.00
R / Rfree (%) 19.8 / 25

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form) (pdb code 4loo). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form), PDB code: 4loo:

Fluorine binding site 1 out of 1 in 4loo

Go back to Fluorine Binding Sites List in 4loo
Fluorine binding site 1 out of 1 in the Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structural Basis of Autoactivation of P38 Alpha Induced By TAB1 (Monoclinic Crystal Form) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F401

b:24.1
occ:1.00
 FB7 A:SB4401 0.0 24.1 1.0
CB3 A:SB4401 1.3 23.3 1.0
CB2 A:SB4401 2.3 20.1 1.0
CB4 A:SB4401 2.3 24.6 1.0
CB A:LEU104 3.3 24.7 1.0
C A:LEU104 3.3 24.5 1.0
O A:LEU104 3.3 24.6 1.0
N A:VAL105 3.4 24.2 1.0
C A:VAL105 3.5 23.8 1.0
CB1 A:SB4401 3.5 21.7 1.0
N A:THR106 3.6 24.0 1.0
CB5 A:SB4401 3.6 21.9 1.0
CA A:VAL105 3.7 24.1 1.0
CB A:THR106 3.8 24.0 1.0
O A:VAL105 3.8 23.6 1.0
CG2 A:THR106 3.9 24.0 1.0
CA A:LEU104 3.9 24.9 1.0
CD2 A:LEU86 4.0 27.6 1.0
CB6 A:SB4401 4.1 24.0 1.0
CA A:THR106 4.3 24.3 1.0
O A:ALA51 4.3 25.7 1.0
CG A:LEU104 4.6 25.2 1.0
CD1 A:LEU104 4.7 25.7 1.0
CD1 A:LEU75 4.7 27.7 1.0
CB A:LYS53 4.8 31.9 1.0
N A:LYS53 4.9 29.4 1.0
OG1 A:THR106 4.9 23.8 1.0

Reference:

G.F.De Nicola, E.D.Martin, A.Chaikuad, R.Bassi, J.Clark, L.Martino, S.Verma, P.Sicard, R.Tata, R.A.Atkinson, S.Knapp, M.R.Conte, M.S.Marber. Mechanism and Consequence of the Autoactivation of P38 Alpha Mitogen-Activated Protein Kinase Promoted By TAB1. Nat.Struct.Mol.Biol. V. 20 1182 2013.
ISSN: ISSN 1545-9993
PubMed: 24037507
DOI: 10.1038/NSMB.2668
Page generated: Sun Dec 13 12:07:08 2020

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