Fluorine in PDB 4mh0: Selective Activation of EPAC1 and EPAC2

The structure of Selective Activation of EPAC1 and EPAC2, PDB code: 4mh0 was solved by H.Rehmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.38 / 2.40
Space group	I 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	125.758, 148.744, 225.165, 90.00, 90.00, 90.00
R / Rfree (%)	26.6 / 28.2

The binding sites of Fluorine atom in the Selective Activation of EPAC1 and EPAC2 (pdb code 4mh0). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Selective Activation of EPAC1 and EPAC2, PDB code: 4mh0:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Selective Activation of EPAC1 and EPAC2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Selective Activation of EPAC1 and EPAC2 within 5.0Å range: probe atom residue distance (Å) B Occ E:F1001 b:46.8 occ:1.00 F1 E:HR41001 0.0 46.8 1.0 C13 E:HR41001 1.3 45.7 1.0 C12 E:HR41001 2.4 45.1 1.0 C14 E:HR41001 2.4 45.5 1.0 OD2 E:ASP401 3.3 42.6 1.0 O E:HOH1240 3.5 42.5 1.0 CG E:ASP401 3.6 42.7 1.0 C11 E:HR41001 3.6 44.4 1.0 C15 E:HR41001 3.6 44.8 1.0 OD1 E:ASP401 3.6 42.8 1.0 C10 E:HR41001 4.1 43.9 1.0 O E:HOH1170 4.3 46.5 1.0 CB E:ASP401 4.6 42.9 1.0 NZ E:LYS450 4.6 54.9 1.0 CD2 E:LEU397 4.6 44.2 1.0 O E:HOH1261 4.7 45.4 1.0

Fluorine binding site 2 out of 2 in the Selective Activation of EPAC1 and EPAC2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Selective Activation of EPAC1 and EPAC2 within 5.0Å range: probe atom residue distance (Å) B Occ E:F1002 b:61.8 occ:1.00 F1 E:HR41002 0.0 61.8 1.0 C13 E:HR41002 1.3 61.0 1.0 C12 E:HR41002 2.4 60.6 1.0 C14 E:HR41002 2.4 60.6 1.0 C11 E:HR41002 3.6 59.9 1.0 C15 E:HR41002 3.7 59.9 1.0 C10 E:HR41002 4.1 59.3 1.0

H.Rehmann, H.Rehmann. N/A N/A.