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Fluorine in PDB 4mne: Crystal Structure of the Braf:MEK1 Complex
Enzymatic activity of Crystal Structure of the Braf:MEK1 Complex
Protein crystallography data
The structure of Crystal Structure of the Braf:MEK1 Complex, PDB code: 4mne
was solved by
J.Sudhamsu,
J.R.Haling,
T.Morales,
B.Brandhuber,
S.G.Hymowitz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 39.59 / 2.85 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 97.498, 135.657, 256.059, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.5 / 24 |
Other elements in 4mne:
The structure of Crystal Structure of the Braf:MEK1 Complex also contains other interesting chemical elements:
| Magnesium | (Mg) | 4 atoms |
| Iodine | (I) | 5 atoms |
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Braf:MEK1 Complex
(pdb code 4mne). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 10 binding sites of Fluorine where determined in the Crystal Structure of the Braf:MEK1 Complex, PDB code: 4mne:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
In total 10 binding sites of Fluorine where determined in the Crystal Structure of the Braf:MEK1 Complex, PDB code: 4mne:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
Fluorine binding site 1 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 1 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 2 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 2 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 3 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 3 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 4 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 4 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 5 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 5 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 6 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 6 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 7 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 7 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 8 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 8 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 9 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 9 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 9 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Fluorine binding site 10 out of 10 in 4mne
Go back to
Fluorine Binding Sites List in 4mne
Fluorine binding site 10 out
of 10 in the Crystal Structure of the Braf:MEK1 Complex
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 10 of Crystal Structure of the Braf:MEK1 Complex within 5.0Å range:
|
Reference:
J.R.Haling,
J.Sudhamsu,
I.Yen,
S.Sideris,
W.Sandoval,
W.Phung,
B.J.Bravo,
A.M.Giannetti,
A.Peck,
A.Masselot,
T.Morales,
D.Smith,
B.J.Brandhuber,
S.G.Hymowitz,
S.Malek.
Structure of the Braf-Mek Complex Reveals A Kinase Activity Independent Role For Braf in Mapk Signaling. Cancer Cell V. 26 402 2014.
ISSN: ISSN 1535-6108
PubMed: 25155755
DOI: 10.1016/J.CCR.2014.07.007
Page generated: Thu Aug 1 03:59:28 2024
ISSN: ISSN 1535-6108
PubMed: 25155755
DOI: 10.1016/J.CCR.2014.07.007
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