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Fluorine in PDB 4ncg: Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv VirusesEnzymatic activity of Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses
All present enzymatic activity of Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; Protein crystallography data
The structure of Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses, PDB code: 4ncg
was solved by
Y.Yan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ncg:
The structure of Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses
(pdb code 4ncg). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses, PDB code: 4ncg: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4ncgGo back to Fluorine Binding Sites List in 4ncg
Fluorine binding site 1 out
of 3 in the Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 4ncgGo back to Fluorine Binding Sites List in 4ncg
Fluorine binding site 2 out
of 3 in the Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 4ncgGo back to Fluorine Binding Sites List in 4ncg
Fluorine binding site 3 out
of 3 in the Discovery of Doravirine, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses
Mono view Stereo pair view
Reference:
B.Cote,
J.D.Burch,
E.Asante-Appiah,
C.Bayly,
L.Bedard,
M.Blouin,
L.C.Campeau,
E.Cauchon,
M.Chan,
A.Chefson,
N.Coulombe,
W.Cromlish,
S.Debnath,
D.Deschenes,
K.Dupont-Gaudet,
J.P.Falgueyret,
R.Forget,
S.Gagne,
D.Gauvreau,
M.Girardin,
S.Guiral,
E.Langlois,
C.S.Li,
N.Nguyen,
R.Papp,
S.Plamondon,
A.Roy,
S.Roy,
R.Seliniotakis,
M.St-Onge,
S.Ouellet,
P.Tawa,
J.F.Truchon,
J.Vacca,
M.Wrona,
Y.Yan,
Y.Ducharme.
Discovery of Mk-1439, An Orally Bioavailable Non-Nucleoside Reverse Transcriptase Inhibitor Potent Against A Wide Range of Resistant Mutant Hiv Viruses. Bioorg.Med.Chem.Lett. V. 24 917 2014.
Page generated: Sun Dec 13 12:08:52 2020
ISSN: ISSN 0960-894X PubMed: 24412110 DOI: 10.1016/J.BMCL.2013.12.070 |
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