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Atomistry » Fluorine » PDB 4o28-4olh » 4obp » |
Fluorine in PDB 4obp: MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-AmineEnzymatic activity of MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-Amine
All present enzymatic activity of MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-Amine:
2.7.11.1; Protein crystallography data
The structure of MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-Amine, PDB code: 4obp
was solved by
S.F.Harris,
P.Wu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4obp:
The structure of MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-Amine also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-Amine
(pdb code 4obp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-Amine, PDB code: 4obp: Fluorine binding site 1 out of 1 in 4obpGo back to Fluorine Binding Sites List in 4obp
Fluorine binding site 1 out
of 1 in the MAP4K4 in Complex with Inhibitor (Compound 29), 6-(2-Fluoropyridin-4- Yl)Pyrido[3,2-D]Pyrimidin-4-Amine
Mono view Stereo pair view
Reference:
T.D.Crawford,
C.O.Ndubaku,
H.Chen,
J.W.Boggs,
B.J.Bravo,
K.Delatorre,
A.M.Giannetti,
S.E.Gould,
S.F.Harris,
S.R.Magnuson,
E.Mcnamara,
L.J.Murray,
J.Nonomiya,
A.Sambrone,
S.Schmidt,
T.Smyczek,
M.Stanley,
P.Vitorino,
L.Wang,
K.West,
P.Wu,
W.Ye.
Discovery of Selective 4-Amino-Pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization. J.Med.Chem. V. 57 3484 2014.
Page generated: Sun Dec 13 12:09:30 2020
ISSN: ISSN 0022-2623 PubMed: 24673130 DOI: 10.1021/JM500155B |
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