Fluorine »
PDB 4olm-4pa0 »
4ovz »
Fluorine in PDB 4ovz: X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
Enzymatic activity of X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
All present enzymatic activity of X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases:
3.4.19.12; 3.4.22.69;
3.4.19.12; 3.4.22.69;
Protein crystallography data
The structure of X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases, PDB code: 4ovz
was solved by
Y.M.Baez-Santos,
A.Mesecar,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 35.75 / 2.50 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 119.772, 73.508, 98.269, 90.00, 103.66, 90.00 |
| R / Rfree (%) | 18.2 / 24.3 |
Other elements in 4ovz:
The structure of X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
(pdb code 4ovz). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases, PDB code: 4ovz:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases, PDB code: 4ovz:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 4ovz
Go back to
Fluorine Binding Sites List in 4ovz
Fluorine binding site 1 out
of 2 in the X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 4ovz
Go back to
Fluorine Binding Sites List in 4ovz
Fluorine binding site 2 out
of 2 in the X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases within 5.0Å range:
|
Reference:
Y.M.Baez-Santos,
S.J.Barraza,
M.W.Wilson,
M.P.Agius,
A.M.Mielech,
N.M.Davis,
S.C.Baker,
S.D.Larsen,
A.D.Mesecar.
X-Ray Structural and Biological Evaluation of A Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases. J.Med.Chem. V. 57 2393 2014.
ISSN: ISSN 1520-4804
PubMed: 24568342
DOI: 10.1021/JM401712T
Page generated: Thu Aug 1 04:41:30 2024
ISSN: ISSN 1520-4804
PubMed: 24568342
DOI: 10.1021/JM401712T
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
