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Fluorine in PDB 4owm: Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium
Enzymatic activity of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium
All present enzymatic activity of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium:
2.4.2.18;
2.4.2.18;
Protein crystallography data
The structure of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium, PDB code: 4owm
was solved by
A.Castell,
T.V.M.Cookson,
F.L.Short,
J.S.Lott,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 73.21 / 1.99 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 79.274, 91.990, 120.892, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17 / 21.3 |
Other elements in 4owm:
The structure of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium also contains other interesting chemical elements:
| Magnesium | (Mg) | 4 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium
(pdb code 4owm). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium, PDB code: 4owm:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium, PDB code: 4owm:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 4owm
Go back to
Fluorine Binding Sites List in 4owm
Fluorine binding site 1 out
of 2 in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 4owm
Go back to
Fluorine Binding Sites List in 4owm
Fluorine binding site 2 out
of 2 in the Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Anthranilate Phosphoribosyl Transferase From Mycobacterium Tuberculosis in Complex with 3-Fluoroanthranilate, Prpp and Magnesium within 5.0Å range:
|
Reference:
T.V.Cookson,
A.Castell,
E.M.Bulloch,
G.L.Evans,
F.L.Short,
E.N.Baker,
J.S.Lott,
E.J.Parker.
Alternative Substrates Reveal Catalytic Cycle and Key Binding Events in the Reaction Catalysed By Anthranilate Phosphoribosyltransferase From Mycobacterium Tuberculosis. Biochem.J. V. 461 87 2014.
ISSN: ESSN 1470-8728
PubMed: 24712732
DOI: 10.1042/BJ20140209
Page generated: Sun Dec 13 12:10:05 2020
ISSN: ESSN 1470-8728
PubMed: 24712732
DOI: 10.1042/BJ20140209
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