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Atomistry » Fluorine » PDB 4olm-4pa0 » 4oys | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4olm-4pa0 » 4oys » |
Fluorine in PDB 4oys: Crystal Structure of VPS34 in Complex with SAR405.Enzymatic activity of Crystal Structure of VPS34 in Complex with SAR405.
All present enzymatic activity of Crystal Structure of VPS34 in Complex with SAR405.:
2.7.1.137; Protein crystallography data
The structure of Crystal Structure of VPS34 in Complex with SAR405., PDB code: 4oys
was solved by
M.Mathieu,
J.P.Marquette,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4oys:
The structure of Crystal Structure of VPS34 in Complex with SAR405. also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of VPS34 in Complex with SAR405.
(pdb code 4oys). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of VPS34 in Complex with SAR405., PDB code: 4oys: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4oysGo back to Fluorine Binding Sites List in 4oys
Fluorine binding site 1 out
of 3 in the Crystal Structure of VPS34 in Complex with SAR405.
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 4oysGo back to Fluorine Binding Sites List in 4oys
Fluorine binding site 2 out
of 3 in the Crystal Structure of VPS34 in Complex with SAR405.
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 4oysGo back to Fluorine Binding Sites List in 4oys
Fluorine binding site 3 out
of 3 in the Crystal Structure of VPS34 in Complex with SAR405.
Mono view Stereo pair view
Reference:
B.Ronan,
O.Flamand,
L.Vescovi,
C.Dureuil,
L.Durand,
F.Fassy,
M.-F.Bachelot,
A.Lamberton,
M.Mathieu,
T.Bertrand,
J.-P.Marquette,
Y.El-Ahmad,
B.Filoche-Romme,
L.Schio,
C.Garcia-Echeverria,
H.Goulaouic,
B.Pasquier.
Highly Potent and Selective Kinase Inhibitor of VPS34 Affects Vesicle Trafficking and Autophagy, and Synergizes with Mtor Inhibitor in Tumor Cells Nat.Chem.Biol. 2014.
Page generated: Sun Dec 13 12:10:08 2020
ISSN: ISSN 1552-4450 DOI: 10.1038/NCHEMBIO.1681 |
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