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Atomistry » Fluorine » PDB 4pb2-4q0d » 4pfc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4pb2-4q0d » 4pfc » |
Fluorine in PDB 4pfc: Crystal Structure of Insulin Degrading Enzyme Complexed with InhibitorEnzymatic activity of Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
All present enzymatic activity of Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor:
3.4.24.56; Protein crystallography data
The structure of Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor, PDB code: 4pfc
was solved by
Y.Wang,
S.Guo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4pfc:
The structure of Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
(pdb code 4pfc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor, PDB code: 4pfc: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 4pfcGo back to Fluorine Binding Sites List in 4pfc
Fluorine binding site 1 out
of 2 in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 4pfcGo back to Fluorine Binding Sites List in 4pfc
Fluorine binding site 2 out
of 2 in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
Mono view Stereo pair view
Reference:
T.B.Durham,
J.L.Toth,
V.J.Klimkowski,
J.X.Cao,
A.M.Siesky,
J.Alexander-Chacko,
G.Y.Wu,
J.T.Dixon,
J.E.Mcgee,
Y.Wang,
S.Y.Guo,
R.N.Cavitt,
J.Schindler,
S.J.Thibodeaux,
N.A.Calvert,
M.J.Coghlan,
D.K.Sindelar,
M.Christe,
V.V.Kiselyov,
M.D.Michael,
K.W.Sloop.
Dual Exosite-Binding Inhibitors of Insulin-Degrading Enzyme Challenge Its Role As the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem. V. 290 20044 2015.
Page generated: Sun Dec 13 12:10:33 2020
ISSN: ESSN 1083-351X PubMed: 26085101 DOI: 10.1074/JBC.M115.638205 |
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