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Atomistry » Fluorine » PDB 4q0e-4qrc » 4qjc | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4q0e-4qrc » 4qjc » |
Fluorine in PDB 4qjc: Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine)Enzymatic activity of Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine)
All present enzymatic activity of Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine):
1.5.1.3; Protein crystallography data
The structure of Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine), PDB code: 4qjc
was solved by
V.Cody,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine)
(pdb code 4qjc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine), PDB code: 4qjc: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4qjcGo back to Fluorine Binding Sites List in 4qjc
Fluorine binding site 1 out
of 3 in the Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine)
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 4qjcGo back to Fluorine Binding Sites List in 4qjc
Fluorine binding site 2 out
of 3 in the Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine)
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 4qjcGo back to Fluorine Binding Sites List in 4qjc
Fluorine binding site 3 out
of 3 in the Human Dihydrofolate Reductase Ternary Complex with Nadph and Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine- 2,4,6-Triamine)
Mono view Stereo pair view
Reference:
V.Cody,
J.Pace,
O.A.Namjoshi,
A.Gangjee.
Structure-Activity Correlations For Three Pyrido[2,3-D]Pyrimidine Antifolates Binding to Human and Pneumocystis Carinii Dihydrofolate Reductase. Acta Crystallogr F Struct V. 71 799 2015BIOL Commun.
Page generated: Sun Dec 13 12:11:32 2020
ISSN: ESSN 1744-3091 PubMed: 26057816 DOI: 10.1107/S2053230X15008468 |
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