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Fluorine in PDB 4qrc: Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with PonatinibEnzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib
All present enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib, PDB code: 4qrc
was solved by
Z.Huang,
M.Mohammadi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib
(pdb code 4qrc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib, PDB code: 4qrc: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4qrcGo back to Fluorine Binding Sites List in 4qrc
Fluorine binding site 1 out
of 3 in the Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 4qrcGo back to Fluorine Binding Sites List in 4qrc
Fluorine binding site 2 out
of 3 in the Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 4qrcGo back to Fluorine Binding Sites List in 4qrc
Fluorine binding site 3 out
of 3 in the Crystal Structure of the Tyrosine Kinase Domain of Fgf Receptor 4 in Complex with Ponatinib
Mono view Stereo pair view
Reference:
Z.Huang,
L.Tan,
H.Wang,
Y.Liu,
S.Blais,
J.Deng,
T.A.Neubert,
N.S.Gray,
X.Li,
M.Mohammadi.
Dfg-Out Mode of Inhibition By An Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in Fgf Receptors. Acs Chem.Biol. 2014.
Page generated: Sun Dec 13 12:11:49 2020
ISSN: ESSN 1554-8937 PubMed: 25317566 DOI: 10.1021/CB500674S |
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