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Atomistry » Fluorine » PDB 4qte-4rv6 » 4rcd » |
Fluorine in PDB 4rcd: Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene InhibitorEnzymatic activity of Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene Inhibitor
All present enzymatic activity of Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene Inhibitor:
3.4.23.46; Protein crystallography data
The structure of Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene Inhibitor, PDB code: 4rcd
was solved by
D.A.Whittington,
A.M.Long,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4rcd:
The structure of Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene Inhibitor
(pdb code 4rcd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene Inhibitor, PDB code: 4rcd: Fluorine binding site 1 out of 1 in 4rcdGo back to Fluorine Binding Sites List in 4rcd
Fluorine binding site 1 out
of 1 in the Crystal Structure of BACE1 in Complex with A 2-Aminooxazoline 4- Azaxanthene Inhibitor
Mono view Stereo pair view
Reference:
T.A.Dineen,
K.Chen,
A.C.Cheng,
K.Derakhchan,
O.Epstein,
J.Esmay,
D.Hickman,
C.E.Kreiman,
I.E.Marx,
R.C.Wahl,
P.H.Wen,
M.M.Weiss,
D.A.Whittington,
S.Wood,
R.T.Fremeau,
R.D.White,
V.F.Patel.
Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-Yl)-3-((3-Methyloxetan-3-Yl) Ethynyl)-5'H-Spiro[Chromeno[2,3-B]Pyridine-5,4'-Oxazol]-2'- Amine (Amg-8718). J.Med.Chem. V. 57 9811 2014.
Page generated: Sun Dec 13 12:12:00 2020
ISSN: ISSN 0022-2623 PubMed: 25363711 DOI: 10.1021/JM5012676 |
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